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極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性
http://hdl.handle.net/10191/31501
http://hdl.handle.net/10191/315016bcafeb9-8747-46a7-873d-7a62c8ac66bd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
126(5)_248-255.pdf (1.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-01-09 | |||||
| タイトル | ||||||
| タイトル | 極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性 | |||||
| タイトル | ||||||
| タイトル | 極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bronchopulmonary dysplasia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | periventricular leukomalacia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gene polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-6 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | very low birth weight infant | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Interleukin-6 Polymorphism and Bronchopulmonary Dysplasia Risk in Very Low Birth Weight Infants | |||||
| 著者 |
臼田, 東平
× 臼田, 東平 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 67090 | |||||
| 姓名 | Usuda, Touhei | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Back ground: This study aimed to evaluate the role of interleukin (IL)-6-634 polymorphism in neonatal disorders such as bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) in very low birth weight infants. Methods: This prospective cohort study included 202 infants (gestational age at birth was 23-34 weeks and birth weight ranged from 500-1499g). Genotypic analysis (polymerase chain reaction-restriction fragment length polymorphism assays) were performed with DNA extracted from whole-blood samples. Results: Genotype distribution (66.8% CC, 28.2% CG, and 5.0% GG) in this study was similar to that in the adult Japanese population. The duration of O_2 therapy in infants with CG/GG genotypes was significantly longer than that in infants with the CC genotype (CG/GG vs. CC: 40.3±52.2 days vs. 28.4±32.6 days, p <0.05). Infants with CG/GG genotypes were more likely to have received postnatal corticosteroid therapy for BPD than those with the CC genotype (CG/GG vs. CC: 20.9% vs. ll.1%, p =0.05). There was no significant difference in the frequency of PVL among IL-6-634 polymorphisms. Conclusions: This study showed an association between IL-6-634 polymorphism and the duration of oxygen therapy for BPD in very low birth weight infants. This finding suggests that the IL-6-634 polymorphism G allele is an aggravating factor of BPD. IL-6-634 polymorphism is not associated with PVL. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 126, 号 5, p. 248-255, 発行日 2012-05 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
