@article{oai:niigata-u.repo.nii.ac.jp:00009705,
 author = {臼田, 東平},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {Back ground: This study aimed to evaluate the role of interleukin (IL)-6-634 polymorphism in neonatal disorders such as bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) in very low birth weight infants. Methods: This prospective cohort study included 202 infants (gestational age at birth was 23-34 weeks and birth weight ranged from 500-1499g). Genotypic analysis (polymerase chain reaction-restriction fragment length polymorphism assays) were performed with DNA extracted from whole-blood samples. Results: Genotype distribution (66.8% CC, 28.2% CG, and 5.0% GG) in this study was similar to that in the adult Japanese population. The duration of O_2 therapy in infants with CG/GG genotypes was significantly longer than that in infants with the CC genotype (CG/GG vs. CC: 40.3±52.2 days vs. 28.4±32.6 days, p <0.05). Infants with CG/GG genotypes were more likely to have received postnatal corticosteroid therapy for BPD than those with the CC genotype (CG/GG vs. CC: 20.9% vs. ll.1%, p =0.05). There was no significant difference in the frequency of PVL among IL-6-634 polymorphisms. Conclusions: This study showed an association between IL-6-634 polymorphism and the duration of oxygen therapy for BPD in very low birth weight infants. This finding suggests that the IL-6-634 polymorphism G allele is an aggravating factor of BPD. IL-6-634 polymorphism is not associated with PVL.},
 pages = {248--255},
 title = {極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性},
 volume = {126},
 year = {2012}
}