{"created":"2021-03-01T06:13:47.856652+00:00","id":9705,"links":{},"metadata":{"_buckets":{"deposit":"36a05df7-24e3-4555-8e7d-f54d45a624f3"},"_deposit":{"id":"9705","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9705"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009705","sets":["453:456","471:537:538:943"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Interleukin-6 Polymorphism and Bronchopulmonary Dysplasia Risk in Very Low Birth Weight Infants"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"255","bibliographicPageStart":"248","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Back ground: This study aimed to evaluate the role of interleukin (IL)-6-634 polymorphism in neonatal disorders such as bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) in very low birth weight infants. Methods: This prospective cohort study included 202 infants (gestational age at birth was 23-34 weeks and birth weight ranged from 500-1499g). Genotypic analysis (polymerase chain reaction-restriction fragment length polymorphism assays) were performed with DNA extracted from whole-blood samples. Results: Genotype distribution (66.8% CC, 28.2% CG, and 5.0% GG) in this study was similar to that in the adult Japanese population. The duration of O_2 therapy in infants with CG/GG genotypes was significantly longer than that in infants with the CC genotype (CG/GG vs. CC: 40.3±52.2 days vs. 28.4±32.6 days, p <0.05). Infants with CG/GG genotypes were more likely to have received postnatal corticosteroid therapy for BPD than those with the CC genotype (CG/GG vs. CC: 20.9% vs. ll.1%, p =0.05). There was no significant difference in the frequency of PVL among IL-6-634 polymorphisms. Conclusions: This study showed an association between IL-6-634 polymorphism and the duration of oxygen therapy for BPD in very low birth weight infants. This finding suggests that the IL-6-634 polymorphism G allele is an aggravating factor of BPD. IL-6-634 polymorphism is not associated with PVL.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"67090","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Usuda, Touhei"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"臼田, 東平"}],"nameIdentifiers":[{"nameIdentifier":"67089","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"126(5)_248-255.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"126(5)_248-255.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9705/files/126(5)_248-255.pdf"},"version_id":"baecfdee-6fa1-4441-80ac-0f214f76ff64"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bronchopulmonary dysplasia","subitem_subject_scheme":"Other"},{"subitem_subject":"periventricular leukomalacia","subitem_subject_scheme":"Other"},{"subitem_subject":"gene polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-6","subitem_subject_scheme":"Other"},{"subitem_subject":"very low birth weight infant","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性"},{"subitem_title":"極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","943"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-09"},"publish_date":"2015-01-09","publish_status":"0","recid":"9705","relation_version_is_last":true,"title":["極低出生体重児における慢性肺疾患とインターロイキン6遺伝子多型との関連性"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:40.606969+00:00"}