{"_buckets": {"deposit": "8bd5155f-9fb2-480b-9279-76948c860cc5"}, "_deposit": {"id": "9686", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "9686"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00009686", "sets": ["456", "942"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "The Usage Trend of Biologics in Our RA Outpatient Clinic for RA Patients Treated with Biologics (Biologics for the Treatment of Inflammatory Disease)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "289", "bibliographicPageStart": "285", "bibliographicVolumeNumber": "126", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "当院リウマチ外来 (単一施設) における生物学的製剤の使用状況について, 継続率と中止率例につき検討した. 対象は2004年から2010年3月末までに生物学的製剤を導入された関節リウマチ患者205例. インフリキシマブ (IFX群) (49例), エタネルセプト (ETN群) (40例) エタネルセプト+メトトレキサー卜 (ETN+MTX群) (76例) トシリズマブ (TCZ群) (40例) の1年継続率はそれぞれ72.1, 82.0, 83.9, 86.6%, 2年継続率はそれぞれ55.4, 71.4, 77.5, 74.6%であった. また, ETN+MTXが2剤目で選択された場合の継続率は1剤目で選択された場合の継続率よりも有意に低いことが示された. 一方, TCZは2剤目で選択された場合でも1剤目の場合と同等の継続率を維持していた. 無効, 二次無効で中止となった症例はIFX群では13例中6例がエタネルセプトへ, ETN群では7例中6例, およびETN+MTX群では12例中10例がトシリズマブへと変更されていた. 有害事象中止例では計21例中16例 (76%) が生物学的製剤中止のまま経過を見られており, 無効・二次無効で中止となった症例 (34例中4例, 12%) とは対照的であった. 有効で中止となった症例がIFX群で1例, ETN+MTX群で3例, ADA群で1例見られ, 経過観察期間中は生物学的製剤中止にて寛解を維持していた.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "66997", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kondo, Naoki"}]}, {"nameIdentifiers": 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{"creatorNames": [{"creatorName": "和田, 庸子"}], "nameIdentifiers": [{"nameIdentifier": "66993", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "村上, 修一"}], "nameIdentifiers": [{"nameIdentifier": "66994", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "黒田, 毅"}], "nameIdentifiers": [{"nameIdentifier": "66995", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中野, 正明"}], "nameIdentifiers": [{"nameIdentifier": "66996", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "126(6)_285-289.pdf", "filesize": [{"value": "608.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 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