{"created":"2021-03-01T06:13:46.655610+00:00","id":9686,"links":{},"metadata":{"_buckets":{"deposit":"8bd5155f-9fb2-480b-9279-76948c860cc5"},"_deposit":{"id":"9686","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9686"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009686","sets":["453:456","471:537:538:942"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Usage Trend of Biologics in Our RA Outpatient Clinic for RA Patients Treated with Biologics (Biologics for the Treatment of Inflammatory Disease)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"289","bibliographicPageStart":"285","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"当院リウマチ外来 (単一施設) における生物学的製剤の使用状況について, 継続率と中止率例につき検討した. 対象は2004年から2010年3月末までに生物学的製剤を導入された関節リウマチ患者205例. インフリキシマブ (IFX群) (49例), エタネルセプト (ETN群) (40例) エタネルセプト+メトトレキサー卜 (ETN+MTX群) (76例) トシリズマブ (TCZ群) (40例) の1年継続率はそれぞれ72.1, 82.0, 83.9, 86.6%, 2年継続率はそれぞれ55.4, 71.4, 77.5, 74.6%であった. また, ETN+MTXが2剤目で選択された場合の継続率は1剤目で選択された場合の継続率よりも有意に低いことが示された. 一方, TCZは2剤目で選択された場合でも1剤目の場合と同等の継続率を維持していた. 無効, 二次無効で中止となった症例はIFX群では13例中6例がエタネルセプトへ, ETN群では7例中6例, およびETN+MTX群では12例中10例がトシリズマブへと変更されていた. 有害事象中止例では計21例中16例 (76%) が生物学的製剤中止のまま経過を見られており, 無効・二次無効で中止となった症例 (34例中4例, 12%) とは対照的であった. 有効で中止となった症例がIFX群で1例, ETN+MTX群で3例, ADA群で1例見られ, 経過観察期間中は生物学的製剤中止にて寛解を維持していた.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"66997","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kondo, Naoki"}]},{"nameIdentifiers":[{"nameIdentifier":"66998","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujisawa, Junichi"}]},{"nameIdentifiers":[{"nameIdentifier":"66999","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Endo, Naoto"}]},{"nameIdentifiers":[{"nameIdentifier":"67000","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Arai, Katsumitsu"}]},{"nameIdentifiers":[{"nameIdentifier":"67001","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Wada, Yoko"}]},{"nameIdentifiers":[{"nameIdentifier":"67002","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Murakami, Shuichi"}]},{"nameIdentifiers":[{"nameIdentifier":"67003","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kuroda, Takeshi"}]},{"nameIdentifiers":[{"nameIdentifier":"67004","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakano, Masaaki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"近藤, 直樹"}],"nameIdentifiers":[{"nameIdentifier":"66989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤澤, 純一"}],"nameIdentifiers":[{"nameIdentifier":"66990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤, 直人"}],"nameIdentifiers":[{"nameIdentifier":"66991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒井, 勝光"}],"nameIdentifiers":[{"nameIdentifier":"66992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田, 庸子"}],"nameIdentifiers":[{"nameIdentifier":"66993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 修一"}],"nameIdentifiers":[{"nameIdentifier":"66994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黒田, 毅"}],"nameIdentifiers":[{"nameIdentifier":"66995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, 正明"}],"nameIdentifiers":[{"nameIdentifier":"66996","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"126(6)_285-289.pdf","filesize":[{"value":"608.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"126(6)_285-289.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9686/files/126(6)_285-289.pdf"},"version_id":"83148038-0a22-48ba-9d65-79979458fa1f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"関節リウマチ","subitem_subject_scheme":"Other"},{"subitem_subject":"生物学的製剤","subitem_subject_scheme":"Other"},{"subitem_subject":"継続率","subitem_subject_scheme":"Other"},{"subitem_subject":"無効・二次無効","subitem_subject_scheme":"Other"},{"subitem_subject":"有害事象","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"1 当院リウマチ外来における生物学的製剤の使用状況(II.一般講演,各科における生物学的製剤の治療経験,第663回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1 当院リウマチ外来における生物学的製剤の使用状況(II.一般講演,各科における生物学的製剤の治療経験,第663回新潟医学会)"},{"subitem_title":"1 当院リウマチ外来における生物学的製剤の使用状況(II.一般講演,各科における生物学的製剤の治療経験,第663回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","942"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-09"},"publish_date":"2015-01-09","publish_status":"0","recid":"9686","relation_version_is_last":true,"title":["1 当院リウマチ外来における生物学的製剤の使用状況(II.一般講演,各科における生物学的製剤の治療経験,第663回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:53:17.673182+00:00"}