{"_buckets": {"deposit": "c0330bfb-bc36-41de-970d-cf4dff358724"}, "_deposit": {"id": "9496", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "9496"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00009496", "sets": ["456", "936"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Histopathologic and Immunohistochemical Study of GIST (Gastrointestinal Stromal Tumor) with Secondary Resistant to Imatinib"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "684", "bibliographicPageStart": "674", "bibliographicVolumeNumber": "126", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "消化管間葉系腫瘍(Gastrointestinal Stromal Tumor: GIST)に対しては, 選択的チロシンキナーゼ阻害薬であるメシル酸イマチニブが抗腫瘍効果を発揮するが, その半数以上で遅発性に薬剤耐性を示す腫瘍が出現し, これらはメシル酸イマチニブ二次耐性GISTと呼ばれている. 本研究では, メシル酸イマチニブ二次耐性GIST12症例27腫瘍病巣の病理組織学的・免疫組織学的特徴およびそれらの腫瘍内多様性について検討した. 主組織型は紡錘形細胞型が過半数例(17/27, 63.0%)を占め, 免疫染色結果はKIT陽性が96.3%, CD34陽性率が63.0%, α-SMA陽性率が40.7%であり, デスミンおよびS-100陽性例はなかった. これらの結果は原発GISTと同等であったが, 二次耐性GISTでは, 核分裂数が対物40倍50視野で10個以上, Ki-67 labeling indexが10%以上の高悪性度に分類されるものが高頻度であった(それぞれ59.3%と74.1%). 腫瘍の変性/壊死のパターンと腫瘍の増悪形式, 組織型, 増殖活性, 免疫染色態度との間には相関は認めなかった. 27腫瘍中18腫瘍(66.7%)で, 組織型または免疫染色態度で腫瘍内多様性を示しており, 二次耐性GISTでは増殖活性の高い腫瘍細胞集団のpolyclonalな増生が高頻度で起きている可能性が示唆された.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "65722", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Bamba, Takeo"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "番場, 竹生"}], "nameIdentifiers": [{"nameIdentifier": "65721", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "126(12)_674-684.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "126(12)_674-684.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/9496/files/126(12)_674-684.pdf"}, "version_id": "010bef3d-1e64-4bc3-8407-e7c125f1048c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "GIST", "subitem_subject_scheme": "Other"}, {"subitem_subject": "secondary resistant", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Imatinib", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histopathology", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immunohistochemistry", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "イマチニブ二次耐性GIST (Gastrointestinal Stromal Tumor)の病理組織学的・免疫組織学的研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "イマチニブ二次耐性GIST (Gastrointestinal Stromal Tumor)の病理組織学的・免疫組織学的研究"}, {"subitem_title": "イマチニブ二次耐性GIST (Gastrointestinal Stromal Tumor)の病理組織学的・免疫組織学的研究", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "936"], "permalink_uri": "http://hdl.handle.net/10191/35474", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-12-11"}, "publish_date": "2015-12-11", "publish_status": "0", "recid": "9496", "relation": {}, "relation_version_is_last": true, "title": ["イマチニブ二次耐性GIST (Gastrointestinal Stromal Tumor)の病理組織学的・免疫組織学的研究"], "weko_shared_id": null}