{"created":"2021-03-01T06:13:34.714866+00:00","id":9496,"links":{},"metadata":{"_buckets":{"deposit":"c0330bfb-bc36-41de-970d-cf4dff358724"},"_deposit":{"id":"9496","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9496"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009496","sets":["453:456","471:537:538:936"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Histopathologic and Immunohistochemical Study of GIST (Gastrointestinal Stromal Tumor) with Secondary Resistant to Imatinib"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"684","bibliographicPageStart":"674","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"消化管間葉系腫瘍(Gastrointestinal Stromal Tumor: GIST)に対しては, 選択的チロシンキナーゼ阻害薬であるメシル酸イマチニブが抗腫瘍効果を発揮するが, その半数以上で遅発性に薬剤耐性を示す腫瘍が出現し, これらはメシル酸イマチニブ二次耐性GISTと呼ばれている. 本研究では, メシル酸イマチニブ二次耐性GIST12症例27腫瘍病巣の病理組織学的・免疫組織学的特徴およびそれらの腫瘍内多様性について検討した. 主組織型は紡錘形細胞型が過半数例(17/27, 63.0%)を占め, 免疫染色結果はKIT陽性が96.3%, CD34陽性率が63.0%, α-SMA陽性率が40.7%であり, デスミンおよびS-100陽性例はなかった. これらの結果は原発GISTと同等であったが, 二次耐性GISTでは, 核分裂数が対物40倍50視野で10個以上, Ki-67 labeling indexが10%以上の高悪性度に分類されるものが高頻度であった(それぞれ59.3%と74.1%). 腫瘍の変性/壊死のパターンと腫瘍の増悪形式, 組織型, 増殖活性, 免疫染色態度との間には相関は認めなかった. 27腫瘍中18腫瘍(66.7%)で, 組織型または免疫染色態度で腫瘍内多様性を示しており, 二次耐性GISTでは増殖活性の高い腫瘍細胞集団のpolyclonalな増生が高頻度で起きている可能性が示唆された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"65722","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Bamba, Takeo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"番場, 竹生"}],"nameIdentifiers":[{"nameIdentifier":"65721","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"126(12)_674-684.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"126(12)_674-684.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9496/files/126(12)_674-684.pdf"},"version_id":"010bef3d-1e64-4bc3-8407-e7c125f1048c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GIST","subitem_subject_scheme":"Other"},{"subitem_subject":"secondary resistant","subitem_subject_scheme":"Other"},{"subitem_subject":"Imatinib","subitem_subject_scheme":"Other"},{"subitem_subject":"histopathology","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"イマチニブ二次耐性GIST (Gastrointestinal Stromal Tumor)の病理組織学的・免疫組織学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"イマチニブ二次耐性GIST (Gastrointestinal Stromal Tumor)の病理組織学的・免疫組織学的研究"},{"subitem_title":"イマチニブ二次耐性GIST (Gastrointestinal Stromal Tumor)の病理組織学的・免疫組織学的研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","936"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-11"},"publish_date":"2015-12-11","publish_status":"0","recid":"9496","relation_version_is_last":true,"title":["イマチニブ二次耐性GIST (Gastrointestinal Stromal Tumor)の病理組織学的・免疫組織学的研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:32.738485+00:00"}