{"_buckets": {"deposit": "c087cb68-91ed-4190-b77d-489ec8e1adcb"}, "_deposit": {"id": "8905", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8905"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008905", "sets": ["456", "919"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Expression of Pentraxin 3 in Neutrophilic Granules"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "300", "bibliographicPageStart": "289", "bibliographicVolumeNumber": "128", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Pentraxinは免疫反応に重要な役割を果たす5量体の蛋白で, pentraxin 3(PTX3)やC-reactive protein(CRP)はpentraxin superfamilyに属する. PTX3は炎症性刺激に曝されるとマクロファージ, 好中球, 血管内皮細胞など様々な細胞から産生され, 好中球ではPTX3は細胞質内の顆粒に局在する. 好中球の顆粒は1次顆粒, 2次顆粒, 3次顆粒の3種に分けられ, PTX3は2次顆粒(特殊顆粒)に存在すると考えられてきた. しかし, 他の顆粒における局在については不明であった. 本研究では成熟好中球と好中球へ分化誘導した前骨髄球性細胞株HL-60細胞を検討し, すべての顆粒にPTX3が存在することを確認した. IL-8の刺激によって好中球はneutrophil extracellular traps(NETs)と呼ばれる不規則な網状形態を示したが, 3種の顆粒はこのNETsの表面に接着し, PTX3はこれら顆粒と共局在した. 以上の成績からPTX3は好中球の細胞質内および細胞外の顆粒構成抗菌性蛋白と共存し, 生体防御上, 重要な役割を果たしていることが推測された.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "62055", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Olga, Razvina"}]}, {"nameIdentifiers": [{"nameIdentifier": "62056", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ajioka, Yoichi"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "オリガ, ラズビナ"}], "nameIdentifiers": [{"nameIdentifier": "62053", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "味岡, 洋一"}], "nameIdentifiers": [{"nameIdentifier": "62054", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "128(7)_289-300.pdf", "filesize": [{"value": "2.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2500000.0, "url": {"label": "128(7)_289-300.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/8905/files/128(7)_289-300.pdf"}, "version_id": "a4bf2f83-ea5a-4c52-a39f-ad5ab7822ceb"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "pentraxin 3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "免疫組織化学", "subitem_subject_scheme": "Other"}, {"subitem_subject": "好中球", "subitem_subject_scheme": "Other"}, {"subitem_subject": "好中球顆粒", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neutrophil extracellular traps(NETs)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "好中球顆粒におけるPentraxin 3の発現", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "好中球顆粒におけるPentraxin 3の発現"}, {"subitem_title": "好中球顆粒におけるPentraxin 3の発現", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "919"], "permalink_uri": "http://hdl.handle.net/10191/43775", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-09-12"}, "publish_date": "2016-09-12", "publish_status": "0", "recid": "8905", "relation": {}, "relation_version_is_last": true, "title": ["好中球顆粒におけるPentraxin 3の発現"], "weko_shared_id": null}