{"created":"2021-03-01T06:12:56.995003+00:00","id":8905,"links":{},"metadata":{"_buckets":{"deposit":"c087cb68-91ed-4190-b77d-489ec8e1adcb"},"_deposit":{"id":"8905","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8905"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008905","sets":["453:456","471:537:538:919"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Expression of Pentraxin 3 in Neutrophilic Granules"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"300","bibliographicPageStart":"289","bibliographicVolumeNumber":"128","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pentraxinは免疫反応に重要な役割を果たす5量体の蛋白で, pentraxin 3(PTX3)やC-reactive protein(CRP)はpentraxin superfamilyに属する. PTX3は炎症性刺激に曝されるとマクロファージ, 好中球, 血管内皮細胞など様々な細胞から産生され, 好中球ではPTX3は細胞質内の顆粒に局在する. 好中球の顆粒は1次顆粒, 2次顆粒, 3次顆粒の3種に分けられ, PTX3は2次顆粒(特殊顆粒)に存在すると考えられてきた. しかし, 他の顆粒における局在については不明であった. 本研究では成熟好中球と好中球へ分化誘導した前骨髄球性細胞株HL-60細胞を検討し, すべての顆粒にPTX3が存在することを確認した. IL-8の刺激によって好中球はneutrophil extracellular traps(NETs)と呼ばれる不規則な網状形態を示したが, 3種の顆粒はこのNETsの表面に接着し, PTX3はこれら顆粒と共局在した. 以上の成績からPTX3は好中球の細胞質内および細胞外の顆粒構成抗菌性蛋白と共存し, 生体防御上, 重要な役割を果たしていることが推測された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"62055","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Olga, Razvina"}]},{"nameIdentifiers":[{"nameIdentifier":"62056","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ajioka, Yoichi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オリガ, ラズビナ"}],"nameIdentifiers":[{"nameIdentifier":"62053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"味岡, 洋一"}],"nameIdentifiers":[{"nameIdentifier":"62054","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"128(7)_289-300.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"128(7)_289-300.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8905/files/128(7)_289-300.pdf"},"version_id":"a4bf2f83-ea5a-4c52-a39f-ad5ab7822ceb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pentraxin 3","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球顆粒","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil extracellular traps(NETs)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"好中球顆粒におけるPentraxin 3の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"好中球顆粒におけるPentraxin 3の発現"},{"subitem_title":"好中球顆粒におけるPentraxin 3の発現","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","919"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-09-12"},"publish_date":"2016-09-12","publish_status":"0","recid":"8905","relation_version_is_last":true,"title":["好中球顆粒におけるPentraxin 3の発現"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:08.716846+00:00"}