{"_buckets": {"deposit": "60f8b4f7-c32a-4cbf-b0ab-9eb28160e75e"}, "_deposit": {"id": "8678", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8678"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008678", "sets": ["456", "909"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Clinical Aspects of Hypoglycemic Encephalopathy : Toward Understanding the Pathogenesis and Drug Discovery"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "354", "bibliographicPageStart": "350", "bibliographicVolumeNumber": "129", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "低血糖症のなかで，グルコース投与によっても神経症状が改善しない重篤なケースは「低血糖脳症」と区別して呼ばれている．我々は，低血糖脳症の治療薬の開発を目的として，治療標的の同定につながる予後を増悪する因子の検討，および治療薬の評価を行う簡便な動物モデルの開発を行った．前者に関して，臨床像の解析では，血糖値，低血糖状態の持続時間，体温血中乳酸値，治療後高血糖が予後に影響を及ぼす可能性を見出した．また頭部MRIの解析では，異常信号病変の出現に，体温が影響する可能性が示唆された．後者に関しては，平坦脳波を短時間にし，人工呼吸器を使用しない，より生理的な低血糖脳症動物モデル（短時間昏睡モデル）を確立した．今後，これらの知見をもとに，低血糖脳症に対する神経保護療法の開発を目指したい．", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "60454", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Shimohata, Takayoshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "60455", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ikeda, Tetsuhiko"}]}, {"nameIdentifiers": [{"nameIdentifier": "60456", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takahashi, Tetsuya"}]}, {"nameIdentifiers": [{"nameIdentifier": "60457", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kanazawa, Masato"}]}, {"nameIdentifiers": [{"nameIdentifier": "60458", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nishizawa, Masatoyo"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "下畑, 享良"}], "nameIdentifiers": [{"nameIdentifier": "60449", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "池田, 哲彦"}], "nameIdentifiers": 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