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3 低血糖脳症の臨床 : 病態の理解と創薬に向けて(シンポジウム「糖尿病の合併症, 第699回新潟医学会)
http://hdl.handle.net/10191/44112
6976d6be-e3dc-4ece-a9b7-aff293303cd3
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-10-05 | |||||
タイトル | ||||||
タイトル | 3 低血糖脳症の臨床 : 病態の理解と創薬に向けて(シンポジウム「糖尿病の合併症, 第699回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 3 低血糖脳症の臨床 : 病態の理解と創薬に向けて(シンポジウム「糖尿病の合併症, 第699回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 低血糖脳症 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 予後憎悪因子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 頭部MRI | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 動物モデル | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 創薬 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Clinical Aspects of Hypoglycemic Encephalopathy : Toward Understanding the Pathogenesis and Drug Discovery | |||||
著者 |
下畑, 享良
× 下畑, 享良× 池田, 哲彦× 高橋, 哲哉× 金澤, 雅人× 西澤, 正豊 |
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著者別名 | ||||||
識別子 | ||||||
識別子 | 60454 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Shimohata, Takayoshi | |||||
著者別名 | ||||||
識別子 | ||||||
識別子 | 60455 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Ikeda, Tetsuhiko | |||||
著者別名 | ||||||
識別子 | ||||||
識別子 | 60456 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Takahashi, Tetsuya | |||||
著者別名 | ||||||
識別子 | ||||||
識別子 | 60457 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Kanazawa, Masato | |||||
著者別名 | ||||||
識別子 | ||||||
識別子 | 60458 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Nishizawa, Masatoyo | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 低血糖症のなかで,グルコース投与によっても神経症状が改善しない重篤なケースは「低血糖脳症」と区別して呼ばれている.我々は,低血糖脳症の治療薬の開発を目的として,治療標的の同定につながる予後を増悪する因子の検討,および治療薬の評価を行う簡便な動物モデルの開発を行った.前者に関して,臨床像の解析では,血糖値,低血糖状態の持続時間,体温血中乳酸値,治療後高血糖が予後に影響を及ぼす可能性を見出した.また頭部MRIの解析では,異常信号病変の出現に,体温が影響する可能性が示唆された.後者に関しては,平坦脳波を短時間にし,人工呼吸器を使用しない,より生理的な低血糖脳症動物モデル(短時間昏睡モデル)を確立した.今後,これらの知見をもとに,低血糖脳症に対する神経保護療法の開発を目指したい. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 129, 号 7, p. 350-354, 発行日 2015-07 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |