WEKO3
AND
アイテム
{"_buckets": {"deposit": "60f8b4f7-c32a-4cbf-b0ab-9eb28160e75e"}, "_deposit": {"id": "8678", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8678"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008678"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Clinical Aspects of Hypoglycemic Encephalopathy : Toward Understanding the Pathogenesis and Drug Discovery"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "354", "bibliographicPageStart": "350", "bibliographicVolumeNumber": "129", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u4f4e\u8840\u7cd6\u75c7\u306e\u306a\u304b\u3067\uff0c\u30b0\u30eb\u30b3\u30fc\u30b9\u6295\u4e0e\u306b\u3088\u3063\u3066\u3082\u795e\u7d4c\u75c7\u72b6\u304c\u6539\u5584\u3057\u306a\u3044\u91cd\u7be4\u306a\u30b1\u30fc\u30b9\u306f\u300c\u4f4e\u8840\u7cd6\u8133\u75c7\u300d\u3068\u533a\u5225\u3057\u3066\u547c\u3070\u308c\u3066\u3044\u308b\uff0e\u6211\u3005\u306f\uff0c\u4f4e\u8840\u7cd6\u8133\u75c7\u306e\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3092\u76ee\u7684\u3068\u3057\u3066\uff0c\u6cbb\u7642\u6a19\u7684\u306e\u540c\u5b9a\u306b\u3064\u306a\u304c\u308b\u4e88\u5f8c\u3092\u5897\u60aa\u3059\u308b\u56e0\u5b50\u306e\u691c\u8a0e\uff0c\u304a\u3088\u3073\u6cbb\u7642\u85ac\u306e\u8a55\u4fa1\u3092\u884c\u3046\u7c21\u4fbf\u306a\u52d5\u7269\u30e2\u30c7\u30eb\u306e\u958b\u767a\u3092\u884c\u3063\u305f\uff0e\u524d\u8005\u306b\u95a2\u3057\u3066\uff0c\u81e8\u5e8a\u50cf\u306e\u89e3\u6790\u3067\u306f\uff0c\u8840\u7cd6\u5024\uff0c\u4f4e\u8840\u7cd6\u72b6\u614b\u306e\u6301\u7d9a\u6642\u9593\uff0c\u4f53\u6e29\u8840\u4e2d\u4e73\u9178\u5024\uff0c\u6cbb\u7642\u5f8c\u9ad8\u8840\u7cd6\u304c\u4e88\u5f8c\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u3092\u898b\u51fa\u3057\u305f\uff0e\u307e\u305f\u982d\u90e8MRI\u306e\u89e3\u6790\u3067\u306f\uff0c\u7570\u5e38\u4fe1\u53f7\u75c5\u5909\u306e\u51fa\u73fe\u306b\uff0c\u4f53\u6e29\u304c\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\uff0e\u5f8c\u8005\u306b\u95a2\u3057\u3066\u306f\uff0c\u5e73\u5766\u8133\u6ce2\u3092\u77ed\u6642\u9593\u306b\u3057\uff0c\u4eba\u5de5\u547c\u5438\u5668\u3092\u4f7f\u7528\u3057\u306a\u3044\uff0c\u3088\u308a\u751f\u7406\u7684\u306a\u4f4e\u8840\u7cd6\u8133\u75c7\u52d5\u7269\u30e2\u30c7\u30eb\uff08\u77ed\u6642\u9593\u660f\u7761\u30e2\u30c7\u30eb\uff09\u3092\u78ba\u7acb\u3057\u305f\uff0e\u4eca\u5f8c\uff0c\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u3082\u3068\u306b\uff0c\u4f4e\u8840\u7cd6\u8133\u75c7\u306b\u5bfe\u3059\u308b\u795e\u7d4c\u4fdd\u8b77\u7642\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u3044\uff0e", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "60454", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Shimohata, Takayoshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "60455", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ikeda, Tetsuhiko"}]}, {"nameIdentifiers": [{"nameIdentifier": "60456", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takahashi, Tetsuya"}]}, {"nameIdentifiers": [{"nameIdentifier": "60457", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kanazawa, Masato"}]}, {"nameIdentifiers": [{"nameIdentifier": "60458", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nishizawa, Masatoyo"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e0b\u7551, \u4eab\u826f"}], "nameIdentifiers": [{"nameIdentifier": "60449", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u6c60\u7530, \u54f2\u5f66"}], "nameIdentifiers": [{"nameIdentifier": "60450", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u9ad8\u6a4b, \u54f2\u54c9"}], "nameIdentifiers": [{"nameIdentifier": "60451", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u91d1\u6fa4, \u96c5\u4eba"}], "nameIdentifiers": [{"nameIdentifier": "60452", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u897f\u6fa4, \u6b63\u8c4a"}], "nameIdentifiers": [{"nameIdentifier": "60453", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "129(7)_350-354.pdf", "filesize": [{"value": "2.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2500000.0, "url": {"label": "129(7)_350-354.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/8678/files/129(7)_350-354.pdf"}, "version_id": "b21dc0a8-47c6-470e-b1dd-179ebd551892"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u4f4e\u8840\u7cd6\u8133\u75c7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4e88\u5f8c\u618e\u60aa\u56e0\u5b50", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u982d\u90e8MRI", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u52d5\u7269\u30e2\u30c7\u30eb", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5275\u85ac", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "3 \u4f4e\u8840\u7cd6\u8133\u75c7\u306e\u81e8\u5e8a : \u75c5\u614b\u306e\u7406\u89e3\u3068\u5275\u85ac\u306b\u5411\u3051\u3066\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u300c\u7cd6\u5c3f\u75c5\u306e\u5408\u4f75\u75c7, \u7b2c699\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "3 \u4f4e\u8840\u7cd6\u8133\u75c7\u306e\u81e8\u5e8a : \u75c5\u614b\u306e\u7406\u89e3\u3068\u5275\u85ac\u306b\u5411\u3051\u3066\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u300c\u7cd6\u5c3f\u75c5\u306e\u5408\u4f75\u75c7, \u7b2c699\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09"}, {"subitem_title": "3 \u4f4e\u8840\u7cd6\u8133\u75c7\u306e\u81e8\u5e8a : \u75c5\u614b\u306e\u7406\u89e3\u3068\u5275\u85ac\u306b\u5411\u3051\u3066\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u300c\u7cd6\u5c3f\u75c5\u306e\u5408\u4f75\u75c7, \u7b2c699\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/909"], "permalink_uri": "http://hdl.handle.net/10191/44112", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-10-05"}, "publish_date": "2016-10-05", "publish_status": "0", "recid": "8678", "relation": {}, "relation_version_is_last": true, "title": ["3 \u4f4e\u8840\u7cd6\u8133\u75c7\u306e\u81e8\u5e8a : \u75c5\u614b\u306e\u7406\u89e3\u3068\u5275\u85ac\u306b\u5411\u3051\u3066\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u300c\u7cd6\u5c3f\u75c5\u306e\u5408\u4f75\u75c7, \u7b2c699\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09"], "weko_shared_id": null}
3 低血糖脳症の臨床 : 病態の理解と創薬に向けて（シンポジウム「糖尿病の合併症, 第699回新潟医学会）
http://hdl.handle.net/10191/44112
6976d6be-e3dc-4ece-a9b7-aff293303cd3
| 名前 / ファイル | ライセンス | アクション | |
|---|---|---|---|
129(7)_350-354.pdf (2.5 MB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-10-05 | |||||
| タイトル | ||||||
| タイトル | 3 低血糖脳症の臨床 : 病態の理解と創薬に向けて（シンポジウム「糖尿病の合併症, 第699回新潟医学会） | |||||
| タイトル | ||||||
| 言語 | en | |||||
| タイトル | 3 低血糖脳症の臨床 : 病態の理解と創薬に向けて（シンポジウム「糖尿病の合併症, 第699回新潟医学会） | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 低血糖脳症 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 予後憎悪因子 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 頭部MRI | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 動物モデル | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 創薬 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Clinical Aspects of Hypoglycemic Encephalopathy : Toward Understanding the Pathogenesis and Drug Discovery | |||||
| 著者 |
下畑, 享良
× 下畑, 享良× 池田, 哲彦× 高橋, 哲哉× 金澤, 雅人× 西澤, 正豊 |
|||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 60454 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Shimohata, Takayoshi | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 60455 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Ikeda, Tetsuhiko | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 60456 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Takahashi, Tetsuya | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 60457 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Kanazawa, Masato | |||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 60458 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | Nishizawa, Masatoyo | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 低血糖症のなかで，グルコース投与によっても神経症状が改善しない重篤なケースは「低血糖脳症」と区別して呼ばれている．我々は，低血糖脳症の治療薬の開発を目的として，治療標的の同定につながる予後を増悪する因子の検討，および治療薬の評価を行う簡便な動物モデルの開発を行った．前者に関して，臨床像の解析では，血糖値，低血糖状態の持続時間，体温血中乳酸値，治療後高血糖が予後に影響を及ぼす可能性を見出した．また頭部MRIの解析では，異常信号病変の出現に，体温が影響する可能性が示唆された．後者に関しては，平坦脳波を短時間にし，人工呼吸器を使用しない，より生理的な低血糖脳症動物モデル（短時間昏睡モデル）を確立した．今後，これらの知見をもとに，低血糖脳症に対する神経保護療法の開発を目指したい． | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 129, 号 7, p. 350-354, 発行日 2015-07 |
|||||
| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
