{"created":"2021-03-01T06:12:42.554451+00:00","id":8678,"links":{},"metadata":{"_buckets":{"deposit":"60f8b4f7-c32a-4cbf-b0ab-9eb28160e75e"},"_deposit":{"id":"8678","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8678"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008678","sets":["453:456","471:537:538:909"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clinical Aspects of Hypoglycemic Encephalopathy : Toward Understanding the Pathogenesis and Drug Discovery"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"354","bibliographicPageStart":"350","bibliographicVolumeNumber":"129","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"低血糖症のなかで，グルコース投与によっても神経症状が改善しない重篤なケースは「低血糖脳症」と区別して呼ばれている．我々は，低血糖脳症の治療薬の開発を目的として，治療標的の同定につながる予後を増悪する因子の検討，および治療薬の評価を行う簡便な動物モデルの開発を行った．前者に関して，臨床像の解析では，血糖値，低血糖状態の持続時間，体温血中乳酸値，治療後高血糖が予後に影響を及ぼす可能性を見出した．また頭部MRIの解析では，異常信号病変の出現に，体温が影響する可能性が示唆された．後者に関しては，平坦脳波を短時間にし，人工呼吸器を使用しない，より生理的な低血糖脳症動物モデル（短時間昏睡モデル）を確立した．今後，これらの知見をもとに，低血糖脳症に対する神経保護療法の開発を目指したい．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"60454","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shimohata, Takayoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"60455","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ikeda, Tetsuhiko"}]},{"nameIdentifiers":[{"nameIdentifier":"60456","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takahashi, Tetsuya"}]},{"nameIdentifiers":[{"nameIdentifier":"60457","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kanazawa, Masato"}]},{"nameIdentifiers":[{"nameIdentifier":"60458","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nishizawa, 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