{"_buckets": {"deposit": "91387a6a-ae6d-4ab6-8f77-694951197f39"}, "_deposit": {"id": "8456", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8456"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008456", "sets": ["456", "899"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "The　Urinary　Adrenal　Hormone　Analysis　and　Associated　Factors　in Very　Low　Birth　Weight　lnfants"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "292", "bibliographicPageStart": "285", "bibliographicVolumeNumber": "130", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "【緒言】低出生体重児は周産期環境などの影響により, 成長後に高血圧を発症し易い. 一方で, 低出生体重児は腎尿細管機能や副腎機能の未熟性により, 新生児期にナトリウム(Na)欠乏に陥り易い. Naは循環血液量や浸透圧, 血圧の恒常性維持に不可欠であり, その調整には副腎ホルモンが中心的な役割を果たしている. 我々は, 低出生体重児の新生児期Na欠乏による副腎機能への負担が, 将来の血圧上昇に繋がると考えており, 本研究では新生児期の副腎機能を評価し, 関連因子について検討した. 【対象と方法】2010年11月から2013年3月まで新潟大学医歯学総合病院総合周産期母子医療センターNICUに入院した極低出生体重児(very low birth weight;VLBW, 出生体重\u003c1,500g)を対象とした. 生後2週間, 1ヵ月時に血漿Na濃度, 血漿クレアチニン濃度, 尿中Na濃度(UNa), 尿中Cre濃度(UCre)を測定した. 液体クロマトグラフィータンデムマス法(LC-MS/MS)を用いて1ヵ月時の尿中副腎ホルモン(dehydroepiandrosterone;DHEA, アルドステロン, コルチゾール, コルチゾン)濃度(urinary adrenal hormone concentration;UAHC)を測定し, 周産期背景やNaバランスとの関連を検討した. 【結果】対象はVLBW35名(女児57.1%)で在胎期間29.97±3.14週(平均±標準偏差), 出生体重1,094[888-1,306]g(中央値[四分位])であった. 1ヵ月時のUAHCは尿中DHEA/Cre 3.13[1.19-7.47]μg/gCre, 尿中アルドステロン/Cre 7.72[3.72-11.73]μg/gCre, 尿中コルチゾール/Cre 8.80[5.03-17.32]μg/gCre, 尿中コルチゾン/Cre 366.88[207.32-471.52]μg/gCreであった. 1ヵ月時のUNa/Creと全てのUAHCに正の相関を認め, 出生体重と尿中DHEA/Cre(r=-0.344, p=0.043), 尿中アルドステロン/Cre(r=-0.443, p=0.008)に負の相関を認めた. 【結論】LC-MS/MSを用いたVLBWの生後1ヵ月時のUAHCを報告した. 新生児期にNa欠乏に陥り易いVLBWでは副腎機能に負担がかかり, 特に出生体重が小さい児でその負担が強いことが示唆された.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "58961", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kaneko, Takayuki"}]}, {"nameIdentifiers": [{"nameIdentifier": "58962", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Saito, Akihiko"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "金子, 孝之"}], "nameIdentifiers": [{"nameIdentifier": "58959", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "齋藤, 昭彦"}], "nameIdentifiers": [{"nameIdentifier": "58960", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "130(5)_285-292.pdf", "filesize": [{"value": "603.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 603600.0, "url": {"label": "130(5)_285-292.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/8456/files/130(5)_285-292.pdf"}, "version_id": "5fb482fb-5a8b-421b-823e-6c91d8b72b81"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "尿中副腎ホルモン分析", "subitem_subject_scheme": "Other"}, {"subitem_subject": "液体クロマトグラフィータンデムマス法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "新生児期ナトリウム欠乏", "subitem_subject_scheme": "Other"}, {"subitem_subject": "尿中ナトリウム排泄", "subitem_subject_scheme": "Other"}, {"subitem_subject": "低出生体重児", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "極低出生体重児の尿中副腎ホルモン分析と関連因子", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "極低出生体重児の尿中副腎ホルモン分析と関連因子"}, {"subitem_title": "極低出生体重児の尿中副腎ホルモン分析と関連因子", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "899"], "permalink_uri": "http://hdl.handle.net/10191/44393", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-10-19"}, "publish_date": "2016-10-19", "publish_status": "0", "recid": "8456", "relation": {}, "relation_version_is_last": true, "title": ["極低出生体重児の尿中副腎ホルモン分析と関連因子"], "weko_shared_id": null}