{"created":"2021-03-01T06:12:28.445888+00:00","id":8456,"links":{},"metadata":{"_buckets":{"deposit":"91387a6a-ae6d-4ab6-8f77-694951197f39"},"_deposit":{"id":"8456","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8456"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008456","sets":["453:456","471:537:538:899"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The　Urinary　Adrenal　Hormone　Analysis　and　Associated　Factors　in Very　Low　Birth　Weight　lnfants"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"292","bibliographicPageStart":"285","bibliographicVolumeNumber":"130","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【緒言】低出生体重児は周産期環境などの影響により, 成長後に高血圧を発症し易い. 一方で, 低出生体重児は腎尿細管機能や副腎機能の未熟性により, 新生児期にナトリウム(Na)欠乏に陥り易い. Naは循環血液量や浸透圧, 血圧の恒常性維持に不可欠であり, その調整には副腎ホルモンが中心的な役割を果たしている. 我々は, 低出生体重児の新生児期Na欠乏による副腎機能への負担が, 将来の血圧上昇に繋がると考えており, 本研究では新生児期の副腎機能を評価し, 関連因子について検討した. 【対象と方法】2010年11月から2013年3月まで新潟大学医歯学総合病院総合周産期母子医療センターNICUに入院した極低出生体重児(very low birth weight;VLBW, 出生体重<1,500g)を対象とした. 生後2週間, 1ヵ月時に血漿Na濃度, 血漿クレアチニン濃度, 尿中Na濃度(UNa), 尿中Cre濃度(UCre)を測定した. 液体クロマトグラフィータンデムマス法(LC-MS/MS)を用いて1ヵ月時の尿中副腎ホルモン(dehydroepiandrosterone;DHEA, アルドステロン, コルチゾール, コルチゾン)濃度(urinary adrenal hormone concentration;UAHC)を測定し, 周産期背景やNaバランスとの関連を検討した. 【結果】対象はVLBW35名(女児57.1%)で在胎期間29.97±3.14週(平均±標準偏差), 出生体重1,094[888-1,306]g(中央値[四分位])であった. 1ヵ月時のUAHCは尿中DHEA/Cre 3.13[1.19-7.47]μg/gCre, 尿中アルドステロン/Cre 7.72[3.72-11.73]μg/gCre, 尿中コルチゾール/Cre 8.80[5.03-17.32]μg/gCre, 尿中コルチゾン/Cre 366.88[207.32-471.52]μg/gCreであった. 1ヵ月時のUNa/Creと全てのUAHCに正の相関を認め, 出生体重と尿中DHEA/Cre(r=-0.344, p=0.043), 尿中アルドステロン/Cre(r=-0.443, p=0.008)に負の相関を認めた. 【結論】LC-MS/MSを用いたVLBWの生後1ヵ月時のUAHCを報告した. 新生児期にNa欠乏に陥り易いVLBWでは副腎機能に負担がかかり, 特に出生体重が小さい児でその負担が強いことが示唆された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"58961","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kaneko, Takayuki"}]},{"nameIdentifiers":[{"nameIdentifier":"58962","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Saito, Akihiko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金子, 孝之"}],"nameIdentifiers":[{"nameIdentifier":"58959","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤, 昭彦"}],"nameIdentifiers":[{"nameIdentifier":"58960","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"130(5)_285-292.pdf","filesize":[{"value":"603.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"130(5)_285-292.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8456/files/130(5)_285-292.pdf"},"version_id":"5fb482fb-5a8b-421b-823e-6c91d8b72b81"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"尿中副腎ホルモン分析","subitem_subject_scheme":"Other"},{"subitem_subject":"液体クロマトグラフィータンデムマス法","subitem_subject_scheme":"Other"},{"subitem_subject":"新生児期ナトリウム欠乏","subitem_subject_scheme":"Other"},{"subitem_subject":"尿中ナトリウム排泄","subitem_subject_scheme":"Other"},{"subitem_subject":"低出生体重児","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"極低出生体重児の尿中副腎ホルモン分析と関連因子","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"極低出生体重児の尿中副腎ホルモン分析と関連因子"},{"subitem_title":"極低出生体重児の尿中副腎ホルモン分析と関連因子","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","899"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-19"},"publish_date":"2016-10-19","publish_status":"0","recid":"8456","relation_version_is_last":true,"title":["極低出生体重児の尿中副腎ホルモン分析と関連因子"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:42:47.760199+00:00"}