{"_buckets": {"deposit": "8e26b1d2-90fc-4700-8524-7ca7e796720d"}, "_deposit": {"id": "8343", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8343"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008343", "sets": ["456", "890"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Recent Progress of Severe Cutaneous Adverse Drug Reactions （Stevens－Johnson syndrome （SJS）／Toxic Epidermal Necrolysis （TEN）"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "76", "bibliographicPageStart": "70", "bibliographicVolumeNumber": "131", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Stevens－Johnson症候群（SJS）／中毒性表皮壊死症（toxic epidermal necrolysis：TEN）は，主に薬剤が原因で，発熱，広範囲の紅斑，びらん・水庖，粘膜症状を伴う重篤な疾患である．SJS／TENの基本的な病態は，表皮細胞と粘膜上皮細胞の細胞死による，表皮や粘膜上皮の壊死性変化である．TENの90％以上がSJSで発症しその後急速にTENに進展することから， SJSとTENは一連の病態と考えられている．SJS／TENの発症機序は不明なことが多いが，最近の研究から次第にそのメカニズムが明らかになりつつある．これまで本症の疾患関連遺伝子としてHLAが知られていたが，その他に薬剤代謝酵素の遺伝子多型との相関も明らかになった．さらに本症特有の表細胞死の機序に新規細胞死メカニズム（ネクロプトーシス）が関わることも明らかになった．臨床においては最近本症における診断基準・診療指針が改定され，治療成績の改善が期待されている．", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "58432", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Abe, Riichiro"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "阿部, 理一郎"}], "nameIdentifiers": [{"nameIdentifier": "58431", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "131(2)_70-76.pdf", "filesize": [{"value": "996.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 996200.0, "url": {"label": "131(2)_70-76.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/8343/files/131(2)_70-76.pdf"}, "version_id": "be696c67-5652-4a07-b54d-bf1e5f9cbdff"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Stevens－Johnson syndrome（SJS）", "subitem_subject_scheme": "Other"}, {"subitem_subject": "toxic epidermal necrolysis（TEN）", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Stevens－Johnson症候群", "subitem_subject_scheme": "Other"}, {"subitem_subject": "中毒性表皮壊死症", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見"}, {"subitem_title": "重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "890"], "permalink_uri": "http://hdl.handle.net/10191/47910", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-09-19"}, "publish_date": "2017-09-19", "publish_status": "0", "recid": "8343", "relation": {}, "relation_version_is_last": true, "title": ["重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見"], "weko_shared_id": null}