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重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見
http://hdl.handle.net/10191/47910
9f70c3ec-895a-4707-b5ea-ba3a155fcc97
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-09-19 | |||||
タイトル | ||||||
タイトル | 重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stevens-Johnson syndrome(SJS) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | toxic epidermal necrolysis(TEN) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stevens-Johnson症候群 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 中毒性表皮壊死症 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Recent Progress of Severe Cutaneous Adverse Drug Reactions (Stevens-Johnson syndrome (SJS)/Toxic Epidermal Necrolysis (TEN) | |||||
著者 |
阿部, 理一郎
× 阿部, 理一郎 |
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著者別名 | ||||||
識別子 | ||||||
識別子 | 58432 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Abe, Riichiro | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Stevens-Johnson症候群(SJS)/中毒性表皮壊死症(toxic epidermal necrolysis:TEN)は,主に薬剤が原因で,発熱,広範囲の紅斑,びらん・水庖,粘膜症状を伴う重篤な疾患である.SJS/TENの基本的な病態は,表皮細胞と粘膜上皮細胞の細胞死による,表皮や粘膜上皮の壊死性変化である.TENの90%以上がSJSで発症しその後急速にTENに進展することから, SJSとTENは一連の病態と考えられている.SJS/TENの発症機序は不明なことが多いが,最近の研究から次第にそのメカニズムが明らかになりつつある.これまで本症の疾患関連遺伝子としてHLAが知られていたが,その他に薬剤代謝酵素の遺伝子多型との相関も明らかになった.さらに本症特有の表細胞死の機序に新規細胞死メカニズム(ネクロプトーシス)が関わることも明らかになった.臨床においては最近本症における診断基準・診療指針が改定され,治療成績の改善が期待されている. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 131, 号 2, p. 70-76, 発行日 2017-02 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |