{"created":"2021-03-01T06:12:21.362671+00:00","id":8343,"links":{},"metadata":{"_buckets":{"deposit":"8e26b1d2-90fc-4700-8524-7ca7e796720d"},"_deposit":{"id":"8343","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8343"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008343","sets":["453:456","471:537:538:890"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Recent Progress of Severe Cutaneous Adverse Drug Reactions （Stevens－Johnson syndrome （SJS）／Toxic Epidermal Necrolysis （TEN）"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"76","bibliographicPageStart":"70","bibliographicVolumeNumber":"131","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Stevens－Johnson症候群（SJS）／中毒性表皮壊死症（toxic epidermal necrolysis：TEN）は，主に薬剤が原因で，発熱，広範囲の紅斑，びらん・水庖，粘膜症状を伴う重篤な疾患である．SJS／TENの基本的な病態は，表皮細胞と粘膜上皮細胞の細胞死による，表皮や粘膜上皮の壊死性変化である．TENの90％以上がSJSで発症しその後急速にTENに進展することから， SJSとTENは一連の病態と考えられている．SJS／TENの発症機序は不明なことが多いが，最近の研究から次第にそのメカニズムが明らかになりつつある．これまで本症の疾患関連遺伝子としてHLAが知られていたが，その他に薬剤代謝酵素の遺伝子多型との相関も明らかになった．さらに本症特有の表細胞死の機序に新規細胞死メカニズム（ネクロプトーシス）が関わることも明らかになった．臨床においては最近本症における診断基準・診療指針が改定され，治療成績の改善が期待されている．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"58432","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abe, Riichiro"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"阿部, 理一郎"}],"nameIdentifiers":[{"nameIdentifier":"58431","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"131(2)_70-76.pdf","filesize":[{"value":"996.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"131(2)_70-76.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8343/files/131(2)_70-76.pdf"},"version_id":"be696c67-5652-4a07-b54d-bf1e5f9cbdff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Stevens－Johnson syndrome（SJS）","subitem_subject_scheme":"Other"},{"subitem_subject":"toxic epidermal necrolysis（TEN）","subitem_subject_scheme":"Other"},{"subitem_subject":"Stevens－Johnson症候群","subitem_subject_scheme":"Other"},{"subitem_subject":"中毒性表皮壊死症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見"},{"subitem_title":"重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","890"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-19"},"publish_date":"2017-09-19","publish_status":"0","recid":"8343","relation_version_is_last":true,"title":["重症型薬疹 (Stevens-Johnson症候群 (SJS) / 中毒性表皮壊死症 (toxic epidermal necrolysis : TEN)) の最近の知見"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:42:41.841608+00:00"}