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Endothelial Cell Injury caused by 15-HPETE, a Lipoxygenase Product of Arachidonic acid
http://hdl.handle.net/10191/33494
http://hdl.handle.net/10191/33494cc91ffb1-c737-4817-9f3e-e94d4d38a6df
名前 / ファイル | ライセンス | アクション |
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38(Suppl.)_21-29.pdf (3.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-01 | |||||
タイトル | ||||||
タイトル | Endothelial Cell Injury caused by 15-HPETE, a Lipoxygenase Product of Arachidonic acid | |||||
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言語 | en | |||||
タイトル | Endothelial Cell Injury caused by 15-HPETE, a Lipoxygenase Product of Arachidonic acid | |||||
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言語 | eng | |||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Ochi, Hiroshi
× Ochi, Hiroshi× Morita, Ikuo× Murota, Sei-itsu |
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内容記述タイプ | Abstract | |||||
内容記述 | Among various arachidonic acid metabolites examined, only 15 (S)-hydroperoxy-5, 8, 11, 13-eicosatetraenoic acid (15-HPETE) caused severe injury to bovine endothelial cells in culture. This cellular injury was time- and dose-dependent. When compared with tertiary-butylhydroperoxide (t-BuOOH) and hydrogen peroxide (H_2O_2), it revealed that the injury caused by 15-HPETE was essentially distinct from those by tBuOOH and H_2O_2 in such respects as temperature dependency and albumin effect. When the endothelial monolayers were exposed to 15-HPETE, prostacyclin (PGI_2) production was markedly suppressed. However, there were discrepancies in time course and dose dependence between 15-HPETE-induced cellular injury and 15-HPETE-induced inhibition of PGI_2 synthesis. In addition, the injurious activity of 15-HPETE was not enhanced even when endothelial monolayers were pretreated with inhibitors of PGI_2 production, suggesting that endogenous PGI_2 does not play any cytoprocective role in endothelial cells at least against such a lipid peroxide as 15-HPETE. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 38(Supplement), p. 21-29, 発行日 1990-03 |
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出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |