{"created":"2021-03-01T06:10:31.522255+00:00","id":6610,"links":{},"metadata":{"_buckets":{"deposit":"24cfb469-8f8d-41f2-a91e-dfdecfa7dc38"},"_deposit":{"id":"6610","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6610"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006610","sets":["453:456","471:537:568:643"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"29","bibliographicPageStart":"21","bibliographicVolumeNumber":"38(Supplement)","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Among various arachidonic acid metabolites examined, only 15 (S)-hydroperoxy-5, 8, 11, 13-eicosatetraenoic acid (15-HPETE) caused severe injury to bovine endothelial cells in culture. This cellular injury was time- and dose-dependent. When compared with tertiary-butylhydroperoxide (t-BuOOH) and hydrogen peroxide (H_2O_2), it revealed that the injury caused by 15-HPETE was essentially distinct from those by tBuOOH and H_2O_2 in such respects as temperature dependency and albumin effect. When the endothelial monolayers were exposed to 15-HPETE, prostacyclin (PGI_2) production was markedly suppressed. However, there were discrepancies in time course and dose dependence between 15-HPETE-induced cellular injury and 15-HPETE-induced inhibition of PGI_2 synthesis. In addition, the injurious activity of 15-HPETE was not enhanced even when endothelial monolayers were pretreated with inhibitors of PGI_2 production, suggesting that endogenous PGI_2 does not play any cytoprocective role in endothelial cells at least against such a lipid peroxide as 15-HPETE.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ochi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"53657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morita, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"53658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murota, Sei-itsu"}],"nameIdentifiers":[{"nameIdentifier":"53659","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"38(Suppl.)_21-29.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"38(Suppl.)_21-29.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6610/files/38(Suppl.)_21-29.pdf"},"version_id":"3c9f68ba-a423-4f71-84fb-07445e3f8d88"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Endothelial Cell Injury caused by 15-HPETE, a Lipoxygenase Product of Arachidonic acid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Endothelial Cell Injury caused by 15-HPETE, a Lipoxygenase Product of Arachidonic acid"},{"subitem_title":"Endothelial Cell Injury caused by 15-HPETE, a Lipoxygenase Product of Arachidonic acid","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-01"},"publish_date":"2015-10-01","publish_status":"0","recid":"6610","relation_version_is_last":true,"title":["Endothelial Cell Injury caused by 15-HPETE, a Lipoxygenase Product of Arachidonic acid"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:55.365980+00:00"}