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Decreased Plasma α_1-antiproteinase Inhibitor Activity in Idiopathic Nephrotic Syndrome
http://hdl.handle.net/10191/33447
http://hdl.handle.net/10191/33447a6793287-e7f8-4b6e-9be1-d5731fe207fa
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-09-28 | |||||
タイトル | ||||||
タイトル | Decreased Plasma α_1-antiproteinase Inhibitor Activity in Idiopathic Nephrotic Syndrome | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Decreased Plasma α_1-antiproteinase Inhibitor Activity in Idiopathic Nephrotic Syndrome | |||||
言語 | ||||||
言語 | eng | |||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Asami, Tadashi
× Asami, Tadashi× Fujii, Mieko× Sakai, Kaoru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent reports on a possible role for neutral proteinase(s), mainly serine proteinase(s), in the development of the nephrotic syndrome have prompted us to investigate the proteinase inhibitor activity of plasma α_1-proteinase inhibitor (α_1-PI, formerly referred to α_1-antitrypsin), which regulates a wide range of serine proteinases, including elastase. The concentration of plasma α_1-PI was significantly lower in idiopathic nephrotic syndrome (INS) both during relapse and in remission than in either chance proteinuria and/or haematuria or normal controls. The anti-elastase activity, one of the serine proteinase inhibitor effects of α_1-PI, was also decreased both during relapse and remission of INS. In contrast, the anti-trypsin activity was decreased upon relapse but normal in remission. The concentration of plasma α_1-PI correlated with the plasma anti-elastase activity, but not with the antitrypsin activity. The presence of decreased levels of both plasma α_1-PI inhibitor concentration and antielastase activity, not only during relapse but also in remission of INS, was difficult to explain in the present study, but may be a predisposing factor for the development of proteinuria and resultant nephrotic syndrome. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 39, 号 3, p. 141-145, 発行日 1991-09 |
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出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |