{"created":"2021-03-01T06:10:30.629953+00:00","id":6596,"links":{},"metadata":{"_buckets":{"deposit":"b1e3fd02-4bc4-4e7c-aa4d-1d308f0236ed"},"_deposit":{"id":"6596","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6596"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006596","sets":["453:456","471:537:568:640"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"145","bibliographicPageStart":"141","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent reports on a possible role for neutral proteinase(s), mainly serine proteinase(s), in the development of the nephrotic syndrome have prompted us to investigate the proteinase inhibitor activity of plasma α_1-proteinase inhibitor (α_1-PI, formerly referred to α_1-antitrypsin), which regulates a wide range of serine proteinases, including elastase. The concentration of plasma α_1-PI was significantly lower in idiopathic nephrotic syndrome (INS) both during relapse and in remission than in either chance proteinuria and/or haematuria or normal controls. The anti-elastase activity, one of the serine proteinase inhibitor effects of α_1-PI, was also decreased both during relapse and remission of INS. In contrast, the anti-trypsin activity was decreased upon relapse but normal in remission. The concentration of plasma α_1-PI correlated with the plasma anti-elastase activity, but not with the antitrypsin activity. The presence of decreased levels of both plasma α_1-PI inhibitor concentration and antielastase activity, not only during relapse but also in remission of INS, was difficult to explain in the present study, but may be a predisposing factor for the development of proteinuria and resultant nephrotic syndrome.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asami, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"53616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujii, Mieko"}],"nameIdentifiers":[{"nameIdentifier":"53617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"53618","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"39(3)_141-145.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39(3)_141-145.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6596/files/39(3)_141-145.pdf"},"version_id":"bcb89b6b-1f43-4e3f-9d55-b9d1c3169e1b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Decreased Plasma α_1-antiproteinase Inhibitor Activity in Idiopathic Nephrotic Syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Decreased Plasma α_1-antiproteinase Inhibitor Activity in Idiopathic Nephrotic Syndrome"},{"subitem_title":"Decreased Plasma α_1-antiproteinase Inhibitor Activity in Idiopathic Nephrotic Syndrome","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","640"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"6596","relation_version_is_last":true,"title":["Decreased Plasma α_1-antiproteinase Inhibitor Activity in Idiopathic Nephrotic Syndrome"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:56.191401+00:00"}