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Role of Reactive Oxygen Species in Adriamycin Induced Nephrosis
http://hdl.handle.net/10191/33461
http://hdl.handle.net/10191/33461647a7795-3d10-4093-939b-a995a4bdcd76
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
39(Suppl.)_63-66.pdf (505.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-28 | |||||
| タイトル | ||||||
| タイトル | Role of Reactive Oxygen Species in Adriamycin Induced Nephrosis | |||||
| タイトル | ||||||
| タイトル | Role of Reactive Oxygen Species in Adriamycin Induced Nephrosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Kakuta, S.
× Kakuta, S.× Nagase, M.× Nakamura, K.× Okada, H.× Hidaka, S.× Nagano, T.× Hirose, T.× Hirobe, M. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate the role of reactive oxygen species (ROS) generation in the pathogenesis of adriamycin (ADR) nephropathy, chemiluminescence was measured using isolated glomeruli from ADR rats. The results showed a marked increase of chemiluminescence which paralleled the increase of albuminuria. A superoxide dismutase (SOD) mimic, which enters easily into the cells was administred and a significant decrease of proteinuria was noted. Addition of SOD in vitro inhibited the enhanced chemiluminescence in rats administered with ADR. A slight glomerular cell increase, but no recruitment of leucocytes and/or monocytes/marcrophages, was observed. We therefore conclude that ADR-induced nephropathy is mainly due to ROS generation of intrinsic glomerular cells. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 39(Supplement), p. 63-66, 発行日 1991-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
