@article{oai:niigata-u.repo.nii.ac.jp:00006579,
 author = {Kakuta, S. and Nagase, M. and Nakamura, K. and Okada, H. and Hidaka, S. and Nagano, T. and Hirose, T. and Hirobe, M.},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {To investigate the role of reactive oxygen species (ROS) generation in the pathogenesis of adriamycin (ADR) nephropathy, chemiluminescence was measured using isolated glomeruli from ADR rats. The results showed a marked increase of chemiluminescence which paralleled the increase of albuminuria. A superoxide dismutase (SOD) mimic, which enters easily into the cells was administred and a significant decrease of proteinuria was noted. Addition of SOD in vitro inhibited the enhanced chemiluminescence in rats administered with ADR. A slight glomerular cell increase, but no recruitment of leucocytes and/or monocytes/marcrophages, was observed. We therefore conclude that ADR-induced nephropathy is mainly due to ROS generation of intrinsic glomerular cells.},
 pages = {63--66},
 title = {Role of Reactive Oxygen Species in Adriamycin Induced Nephrosis},
 volume = {39(Supplement)},
 year = {1991}
}