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Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats
http://hdl.handle.net/10191/33246
http://hdl.handle.net/10191/3324630aa2450-4fd8-4586-9585-37cb63908e0f
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42(3)_103-107.pdf (608.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-09-04 | |||||
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タイトル | Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats | |||||
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言語 | en | |||||
タイトル | Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats | |||||
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言語 | eng | |||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Nakatsuji, Tadako
× Nakatsuji, Tadako |
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内容記述タイプ | Abstract | |||||
内容記述 | Iron-related autoimmune disturbances were studied in male amd female Lewis rats. Among 16 males injected with Wister rat liver ferritin, one injected with only the ferritin showed non-hemolytic autoimmune disturbances. A 49 g weight loss, 9.7% siderocytes, high titer anti-nuclear antibody to hepatic nucleus (92%) and low titer auto-red blood cell (RBC) antibody were recognized in this rat. Another male was diagnosed with autoimmune hemolytic anemia after treatment with both the ferritin and anti-Ia monoclonal antibody (mAb) to major histocompatibility complex (MHC) class II, Ia antigen. Auto-RBC antibody was identified in this animal. Mildly or moderately disturbed self-recognitions were found in 5 males treated with ferritin and anti-Ia mAb. On the other hand, all 15 females showed weaker autoimmunity than the males in the same experimental systems. Females differed from males in two points: First, increased iron depositions in proximal convoluted renal tubules were observed in all females injected with the ferritin, especially in one of the females treated together with anti-IA (MHC class I) mAb. Second, atrophic medullae with a relatively hyperplastic cortex were shown in the adrenal glands of 3 females. Among 11 previously pregnant females, 6 had the same atrophic medullae. These data suggested the following two conclusions: 1) Disturbed iron incorporation in mitochondria is an important trigger of pre-autoimmune hemolysis in male rats; 2) In female rats, the adrenal and renal tubule axis reacts to improve self-recognition based on immunohemopoietic actions. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 42, 号 3, p. 103-107, 発行日 1994-09 |
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出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |