{"created":"2021-03-01T06:10:24.214745+00:00","id":6494,"links":{},"metadata":{"_buckets":{"deposit":"39f82f23-8a9f-4f94-8ca7-17ce4656c5f5"},"_deposit":{"id":"6494","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6494"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006494","sets":["453:456","471:537:568:626"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"107","bibliographicPageStart":"103","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Iron-related autoimmune disturbances were studied in male amd female Lewis rats. Among 16 males injected with Wister rat liver ferritin, one injected with only the ferritin showed non-hemolytic autoimmune disturbances. A 49 g weight loss, 9.7% siderocytes, high titer anti-nuclear antibody to hepatic nucleus (92%) and low titer auto-red blood cell (RBC) antibody were recognized in this rat. Another male was diagnosed with autoimmune hemolytic anemia after treatment with both the ferritin and anti-Ia monoclonal antibody (mAb) to major histocompatibility complex (MHC) class II, Ia antigen. Auto-RBC antibody was identified in this animal. Mildly or moderately disturbed self-recognitions were found in 5 males treated with ferritin and anti-Ia mAb. On the other hand, all 15 females showed weaker autoimmunity than the males in the same experimental systems. Females differed from males in two points: First, increased iron depositions in proximal convoluted renal tubules were observed in all females injected with the ferritin, especially in one of the females treated together with anti-IA (MHC class I) mAb. Second, atrophic medullae with a relatively hyperplastic cortex were shown in the adrenal glands of 3 females. Among 11 previously pregnant females, 6 had the same atrophic medullae. These data suggested the following two conclusions: 1) Disturbed iron incorporation in mitochondria is an important trigger of pre-autoimmune hemolysis in male rats; 2) In female rats, the adrenal and renal tubule axis reacts to improve self-recognition based on immunohemopoietic actions.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakatsuji, Tadako"}],"nameIdentifiers":[{"nameIdentifier":"53198","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"42(3)_103-107.pdf","filesize":[{"value":"608.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"42(3)_103-107.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6494/files/42(3)_103-107.pdf"},"version_id":"36b8c27a-d1e3-4803-b24b-bff17feb882d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats"},{"subitem_title":"Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","626"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-04"},"publish_date":"2015-09-04","publish_status":"0","recid":"6494","relation_version_is_last":true,"title":["Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:50.277581+00:00"}