@article{oai:niigata-u.repo.nii.ac.jp:00006494,
 author = {Nakatsuji, Tadako},
 issue = {3},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Sep},
 note = {Iron-related autoimmune disturbances were studied in male amd female Lewis rats. Among 16 males injected with Wister rat liver ferritin, one injected with only the ferritin showed non-hemolytic autoimmune disturbances. A 49 g weight loss, 9.7% siderocytes, high titer anti-nuclear antibody to hepatic nucleus (92%) and low titer auto-red blood cell (RBC) antibody were recognized in this rat. Another male was diagnosed with autoimmune hemolytic anemia after treatment with both the ferritin and anti-Ia monoclonal antibody (mAb) to major histocompatibility complex (MHC) class II, Ia antigen. Auto-RBC antibody was identified in this animal. Mildly or moderately disturbed self-recognitions were found in 5 males treated with ferritin and anti-Ia mAb. On the other hand, all 15 females showed weaker autoimmunity than the males in the same experimental systems. Females differed from males in two points: First, increased iron depositions in proximal convoluted renal tubules were observed in all females injected with the ferritin, especially in one of the females treated together with anti-IA (MHC class I) mAb. Second, atrophic medullae with a relatively hyperplastic cortex were shown in the adrenal glands of 3 females. Among 11 previously pregnant females, 6 had the same atrophic medullae. These data suggested the following two conclusions: 1) Disturbed iron incorporation in mitochondria is an important trigger of pre-autoimmune hemolysis in male rats; 2) In female rats, the adrenal and renal tubule axis reacts to improve self-recognition based on immunohemopoietic actions.},
 pages = {103--107},
 title = {Iron-related Autoimmune Hemolysis : Inductive and Competitive Reactions Found in Lewis Rats},
 volume = {42},
 year = {1994}
}