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Methods: The reactivity of lymphocytes against spouse\u0027s lymphocytes in a mixed lymphocyte culture reaction (MLR) was serially evaluated in married female patients with unexplained recurrent abortion who underwent immunotherapy. Results: Reactivity against the spouse\u0027s lymphocytes significantly decreased after immunotherapy compared with that before therapy (n=19, p\u003c0.01, Wilcoxon test). Reactivity during the first trimester of the new pregnancy was also significantly lower than that before immunotherapy in married female patients with a successful outcome (n=9, p\u003c 0.05, Wilcoxon test). Reactivity in MLR, however, was significantly higher in married female patients who subsequently had repeated spontaneous abortion (n=4, p\u003c0.05, Wilcoxon test). 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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.43 No.4

MLR Reactivity against Spouse's Lymphocytes : Successful Cases with Unexplained Recurrent Abortion Treated by Immunotherapy with Spouse's Cells

http://hdl.handle.net/10191/33219
http://hdl.handle.net/10191/33219
ca9ded92-88ed-4f07-bedc-e060de645496
名前 / ファイル ライセンス アクション
43(4)_211-216.pdf 43(4)_211-216.pdf (572.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-31
タイトル
タイトル MLR Reactivity against Spouse's Lymphocytes : Successful Cases with Unexplained Recurrent Abortion Treated by Immunotherapy with Spouse's Cells
タイトル
言語 en
タイトル MLR Reactivity against Spouse's Lymphocytes : Successful Cases with Unexplained Recurrent Abortion Treated by Immunotherapy with Spouse's Cells
言語
言語 eng
キーワード
主題Scheme Other
主題 recurrent abortion
キーワード
主題Scheme Other
主題 immunotherapy
キーワード
主題Scheme Other
主題 MLR
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Kazama, Yoshiki

× Kazama, Yoshiki

WEKO 53026

Kazama, Yoshiki

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Takakuwa, Koichi

× Takakuwa, Koichi

WEKO 53027

Takakuwa, Koichi

Search repository
Tanaka, Kenichi

× Tanaka, Kenichi

WEKO 53028

Tanaka, Kenichi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Problem: What are the possible underlying mechanisms of immunotherapy for unexplained recurrent abortion using spouse's cells? Methods: The reactivity of lymphocytes against spouse's lymphocytes in a mixed lymphocyte culture reaction (MLR) was serially evaluated in married female patients with unexplained recurrent abortion who underwent immunotherapy. Results: Reactivity against the spouse's lymphocytes significantly decreased after immunotherapy compared with that before therapy (n=19, p<0.01, Wilcoxon test). Reactivity during the first trimester of the new pregnancy was also significantly lower than that before immunotherapy in married female patients with a successful outcome (n=9, p< 0.05, Wilcoxon test). Reactivity in MLR, however, was significantly higher in married female patients who subsequently had repeated spontaneous abortion (n=4, p<0.05, Wilcoxon test). Conclusion: It is suggested that the attenuation of the reactivity against the spouse's lymphocytes might be implicated in the successful pregnancy of patients with unexplained recurrent abortion who underwent the immunotherapy.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 43, 号 4, p. 211-216, 発行日 1995-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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