@article{oai:niigata-u.repo.nii.ac.jp:00006456, author = {Kazama, Yoshiki and Takakuwa, Koichi and Tanaka, Kenichi}, issue = {4}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Dec}, note = {Problem: What are the possible underlying mechanisms of immunotherapy for unexplained recurrent abortion using spouse's cells? Methods: The reactivity of lymphocytes against spouse's lymphocytes in a mixed lymphocyte culture reaction (MLR) was serially evaluated in married female patients with unexplained recurrent abortion who underwent immunotherapy. Results: Reactivity against the spouse's lymphocytes significantly decreased after immunotherapy compared with that before therapy (n=19, p<0.01, Wilcoxon test). Reactivity during the first trimester of the new pregnancy was also significantly lower than that before immunotherapy in married female patients with a successful outcome (n=9, p< 0.05, Wilcoxon test). Reactivity in MLR, however, was significantly higher in married female patients who subsequently had repeated spontaneous abortion (n=4, p<0.05, Wilcoxon test). Conclusion: It is suggested that the attenuation of the reactivity against the spouse's lymphocytes might be implicated in the successful pregnancy of patients with unexplained recurrent abortion who underwent the immunotherapy.}, pages = {211--216}, title = {MLR Reactivity against Spouse's Lymphocytes : Successful Cases with Unexplained Recurrent Abortion Treated by Immunotherapy with Spouse's Cells}, volume = {43}, year = {1995} }