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Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC
http://hdl.handle.net/10191/33119
http://hdl.handle.net/10191/33119e1e919bf-003b-41bc-8506-97ae64c6d03d
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-25 | |||||
タイトル | ||||||
タイトル | Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phospholipase A_2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phospholipase C | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | G-proteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human platelets | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Fuse, Ichiro
× Fuse, Ichiro× Higuchi, Wataru× Aizawa, Yoshifusa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the relationship between the activation of phospholipase A_2 (PLA_2) and C (PLC) induced by thrombin in human platelets. Lysophosphatidylinositol (LPI) formation, an indicator of PLA_2 activation, was completely inhibited by pretreatment with pertussis toxin, but inositol-1, 4, 5-triphosphate (IP_3) formation, an indicator of PLC activation, was reduced by about 50%. Prostaglandin E_1 inhibited IP_3 formation completely, but only reduced LPI formation by about 50%. However, cholera toxin did not affect either formation. Conclusion: 1) The differential sensitivity of PLA_2 and PLC to pertussis toxin and PGE_1 strongly suggests that the activity of both enzymes is modulated by distinct GTP- binding proteins; 2) pertussis toxin sensitive G-protein is involved in the thrombin-induced platelet activation process, but cholera toxin is not. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 45, 号 2, p. 45-50, 発行日 1997-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |