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Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC
http://hdl.handle.net/10191/33119
http://hdl.handle.net/10191/33119e1e919bf-003b-41bc-8506-97ae64c6d03d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
45(2)_45-50.pdf (827.0 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-08-25 | |||||
| タイトル | ||||||
| タイトル | Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC | |||||
| タイトル | ||||||
| タイトル | Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | phospholipase A_2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | phospholipase C | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | G-proteins | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | human platelets | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Fuse, Ichiro
× Fuse, Ichiro× Higuchi, Wataru× Aizawa, Yoshifusa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We investigated the relationship between the activation of phospholipase A_2 (PLA_2) and C (PLC) induced by thrombin in human platelets. Lysophosphatidylinositol (LPI) formation, an indicator of PLA_2 activation, was completely inhibited by pretreatment with pertussis toxin, but inositol-1, 4, 5-triphosphate (IP_3) formation, an indicator of PLC activation, was reduced by about 50%. Prostaglandin E_1 inhibited IP_3 formation completely, but only reduced LPI formation by about 50%. However, cholera toxin did not affect either formation. Conclusion: 1) The differential sensitivity of PLA_2 and PLC to pertussis toxin and PGE_1 strongly suggests that the activity of both enzymes is modulated by distinct GTP- binding proteins; 2) pertussis toxin sensitive G-protein is involved in the thrombin-induced platelet activation process, but cholera toxin is not. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 45, 号 2, p. 45-50, 発行日 1997-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Fuse, Ichiro, Higuchi, Wataru, Aizawa, Yoshifusa, 1997, Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC: Niigata University School of Medicine, 45–50 p.
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