{"_buckets": {"deposit": "61dec904-d5b6-4040-8526-e8e2c687461b"}, "_deposit": {"id": "6403", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6403"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006403"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "50", "bibliographicPageStart": "45", "bibliographicVolumeNumber": "45", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We investigated the relationship between the activation of phospholipase A_2 (PLA_2) and C (PLC) induced by thrombin in human platelets. Lysophosphatidylinositol (LPI) formation, an indicator of PLA_2 activation, was completely inhibited by pretreatment with pertussis toxin, but inositol-1, 4, 5-triphosphate (IP_3) formation, an indicator of PLC activation, was reduced by about 50%. Prostaglandin E_1 inhibited IP_3 formation completely, but only reduced LPI formation by about 50%. However, cholera toxin did not affect either formation. Conclusion: 1) The differential sensitivity of PLA_2 and PLC to pertussis toxin and PGE_1 strongly suggests that the activity of both enzymes is modulated by distinct GTP- binding proteins; 2) pertussis toxin sensitive G-protein is involved in the thrombin-induced platelet activation process, but cholera toxin is not.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fuse, Ichiro"}], "nameIdentifiers": [{"nameIdentifier": "52737", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Wataru"}], "nameIdentifiers": [{"nameIdentifier": "52738", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aizawa, Yoshifusa"}], "nameIdentifiers": [{"nameIdentifier": "52739", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "45(2)_45-50.pdf", "filesize": [{"value": "827.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 827000.0, "url": {"label": "45(2)_45-50.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6403/files/45(2)_45-50.pdf"}, "version_id": "d653a666-1563-414e-95ad-162f35b9eda9"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "phospholipase A_2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "phospholipase C", "subitem_subject_scheme": "Other"}, {"subitem_subject": "G-proteins", "subitem_subject_scheme": "Other"}, {"subitem_subject": "human platelets", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC"}, {"subitem_title": "Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/615"], "permalink_uri": "http://hdl.handle.net/10191/33119", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-25"}, "publish_date": "2015-08-25", "publish_status": "0", "recid": "6403", "relation": {}, "relation_version_is_last": true, "title": ["Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC"], "weko_shared_id": null}