@article{oai:niigata-u.repo.nii.ac.jp:00006403,
 author = {Fuse, Ichiro and Higuchi, Wataru and Aizawa, Yoshifusa},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {We investigated the relationship between the activation of phospholipase A_2 (PLA_2) and C (PLC) induced by thrombin in human platelets. Lysophosphatidylinositol (LPI) formation, an indicator of PLA_2 activation, was completely inhibited by pretreatment with pertussis toxin, but inositol-1, 4, 5-triphosphate (IP_3) formation, an indicator of PLC activation, was reduced by about 50%. Prostaglandin E_1 inhibited IP_3 formation completely, but only reduced LPI formation by about 50%. However, cholera toxin did not affect either formation. Conclusion: 1) The differential sensitivity of PLA_2 and PLC to pertussis toxin and PGE_1 strongly suggests that the activity of both enzymes is modulated by distinct GTP- binding proteins; 2) pertussis toxin sensitive G-protein is involved in the thrombin-induced platelet activation process, but cholera toxin is not.},
 pages = {45--50},
 title = {Interactions between the Activation of Phospholipase A_2(PLA_2) and C(PLC) Induced by Thrombin in Human Platelets : Evidence for the Separate Activation of PLA_2 and PLC},
 volume = {45},
 year = {1997}
}