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Preserved Lusitropic Reserve of the Left Ventricles in Spite of Impaired Inotropic Reserve in Patients with Chronic Heart Failure
http://hdl.handle.net/10191/1878
http://hdl.handle.net/10191/1878a95fcc87-2ab6-4e4d-a2d0-982c418f53c1
名前 / ファイル | ライセンス | アクション |
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KJ00000007255.pdf (2.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | Preserved Lusitropic Reserve of the Left Ventricles in Spite of Impaired Inotropic Reserve in Patients with Chronic Heart Failure | |||||
タイトル | ||||||
タイトル | Preserved Lusitropic Reserve of the Left Ventricles in Spite of Impaired Inotropic Reserve in Patients with Chronic Heart Failure | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic heart failure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | β-adrenoceptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dobutamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inotropic reserve | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lusitropic reserve | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
KODAMA, Makoto
× KODAMA, Makoto× HANAWA, Haruo× KATO, Kiminori× NAKAMURA, Yuichi× OKURA, Yuji× HIRONO, Satoru× ITO, Masahiro× FUSE, Koichi× HOSONO, Hiroyuki× SAEKI, Makihiko× TAKAHASHI, Minoru× KOYAMA, Sen× TSUDA, Takashi× WATANABE, Kenichi× AIZAWA, Yoshifusa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Inotropic and lusitropic reserves of failing hearts were investigated using a stepwise intravenous dobutamine loading test in patients with chronic heart failure. The forty-one patients enrolled in this study were classified into 4 groups according to the left ventricular end-systolic volume indices (LVESVI). The left ventricular size of Group 1 was within the normal range (LVESVI=37.0±3.5ml/m^2), and this group served as the control. LVESVI of Group 2 was mildly dilated (53.9±6.4ml/m^2), that of Group 3 was moderately dilated (77.3±4.7ml/m^2), and Group 4 was severely dilated (120.0±34.9ml/m^2). Left ventricular contractility and relaxation properties were estimated by left ventricular maximum positive dP/dt and minimum negative dP/dt. At the basal condition, both positive dP/dt and the absolute value of negative dP/dt were low in patients with chronic heart failure in accordance with LVESVI. Acceleration of positive dP/dt by dobutamine infusion was more attenuated in Group 4 than that of Group 1. However, responses of negative dP/dt were identical among the 4 groups. Thus, there was a dissociation between inotropic and lusitropic reserves of human failing hearts for β-adrenergic stimulation. These findings imply that a lusitropic reserve is preserved in the failing left ventricles in spite of an impairment to the inotropic reserve. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 48, 号 2, p. 69-74, 発行日 2000-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |