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Preserved Lusitropic Reserve of the Left Ventricles in Spite of Impaired Inotropic Reserve in Patients with Chronic Heart Failure
http://hdl.handle.net/10191/1878
http://hdl.handle.net/10191/1878a95fcc87-2ab6-4e4d-a2d0-982c418f53c1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007255.pdf (2.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Preserved Lusitropic Reserve of the Left Ventricles in Spite of Impaired Inotropic Reserve in Patients with Chronic Heart Failure | |||||
| タイトル | ||||||
| タイトル | Preserved Lusitropic Reserve of the Left Ventricles in Spite of Impaired Inotropic Reserve in Patients with Chronic Heart Failure | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chronic heart failure | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-adrenoceptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dobutamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | inotropic reserve | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lusitropic reserve | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
KODAMA, Makoto
× KODAMA, Makoto× HANAWA, Haruo× KATO, Kiminori× NAKAMURA, Yuichi× OKURA, Yuji× HIRONO, Satoru× ITO, Masahiro× FUSE, Koichi× HOSONO, Hiroyuki× SAEKI, Makihiko× TAKAHASHI, Minoru× KOYAMA, Sen× TSUDA, Takashi× WATANABE, Kenichi× AIZAWA, Yoshifusa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Inotropic and lusitropic reserves of failing hearts were investigated using a stepwise intravenous dobutamine loading test in patients with chronic heart failure. The forty-one patients enrolled in this study were classified into 4 groups according to the left ventricular end-systolic volume indices (LVESVI). The left ventricular size of Group 1 was within the normal range (LVESVI=37.0±3.5ml/m^2), and this group served as the control. LVESVI of Group 2 was mildly dilated (53.9±6.4ml/m^2), that of Group 3 was moderately dilated (77.3±4.7ml/m^2), and Group 4 was severely dilated (120.0±34.9ml/m^2). Left ventricular contractility and relaxation properties were estimated by left ventricular maximum positive dP/dt and minimum negative dP/dt. At the basal condition, both positive dP/dt and the absolute value of negative dP/dt were low in patients with chronic heart failure in accordance with LVESVI. Acceleration of positive dP/dt by dobutamine infusion was more attenuated in Group 4 than that of Group 1. However, responses of negative dP/dt were identical among the 4 groups. Thus, there was a dissociation between inotropic and lusitropic reserves of human failing hearts for β-adrenergic stimulation. These findings imply that a lusitropic reserve is preserved in the failing left ventricles in spite of an impairment to the inotropic reserve. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 48, 号 2, p. 69-74, 発行日 2000-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
KODAMA, Makoto, HANAWA, Haruo, KATO, Kiminori, NAKAMURA, Yuichi, OKURA, Yuji, HIRONO, Satoru, ITO, Masahiro, FUSE, Koichi, HOSONO, Hiroyuki, SAEKI, Makihiko, TAKAHASHI, Minoru, KOYAMA, Sen, TSUDA, Takashi, WATANABE, Kenichi, AIZAWA, Yoshifusa, 2000, Preserved Lusitropic Reserve of the Left Ventricles in Spite of Impaired Inotropic Reserve in Patients with Chronic Heart Failure: Niigata University School of Medicine, 69–74 p.
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