@article{oai:niigata-u.repo.nii.ac.jp:00006332,
 author = {KODAMA, Makoto and HANAWA, Haruo and KATO, Kiminori and NAKAMURA, Yuichi and OKURA, Yuji and HIRONO, Satoru and ITO, Masahiro and FUSE, Koichi and HOSONO, Hiroyuki and SAEKI, Makihiko and TAKAHASHI, Minoru and KOYAMA, Sen and TSUDA, Takashi and WATANABE, Kenichi and AIZAWA, Yoshifusa},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Inotropic and lusitropic reserves of failing hearts were investigated using a stepwise intravenous dobutamine loading test in patients with chronic heart failure. The forty-one patients enrolled in this study were classified into 4 groups according to the left ventricular end-systolic volume indices (LVESVI). The left ventricular size of Group 1 was within the normal range (LVESVI=37.0±3.5ml/m^2), and this group served as the control. LVESVI of Group 2 was mildly dilated (53.9±6.4ml/m^2), that of Group 3 was moderately dilated (77.3±4.7ml/m^2), and Group 4 was severely dilated (120.0±34.9ml/m^2). Left ventricular contractility and relaxation properties were estimated by left ventricular maximum positive dP/dt and minimum negative dP/dt. At the basal condition, both positive dP/dt and the absolute value of negative dP/dt were low in patients with chronic heart failure in accordance with LVESVI. Acceleration of positive dP/dt by dobutamine infusion was more attenuated in Group 4 than that of Group 1. However, responses of negative dP/dt were identical among the 4 groups. Thus, there was a dissociation between inotropic and lusitropic reserves of human failing hearts for β-adrenergic stimulation. These findings imply that a lusitropic reserve is preserved in the failing left ventricles in spite of an impairment to the inotropic reserve.},
 pages = {69--74},
 title = {Preserved Lusitropic Reserve of the Left Ventricles in Spite of Impaired Inotropic Reserve in Patients with Chronic Heart Failure},
 volume = {48},
 year = {2000}
}