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MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma
http://hdl.handle.net/10191/1834
http://hdl.handle.net/10191/183408ef213c-546a-4797-afe2-2f518656160e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004267744.pdf (3.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma | |||||
| タイトル | ||||||
| タイトル | MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ulcerative colitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | colorectal carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MUC1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MUC2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MUC5AC | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mucin phenotype | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Kanoh, Tsunehisa
× Kanoh, Tsunehisa× Ajioka, Yoichi× Watanabe, Hidenobu× Hatakeyama, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mucin core protein expression in ulcerative colitis-associated colorectal carcinoma (UC-CRC) has not been investigated to date. We immunohistochemically examined expression of MUC2, MUC5AC, and MUC1 mucin core proteins in 8 UC-CRCs (4 mucinous carcinomas and 4 well and/or moderately differentiated adenocarcinomas) in order to characterize their mucin phenotypes. We then compared these with sporadic colorectal carcinomas (sporadic CRCs) (30 mucinous carcinomas and 60 well and/or moderately differentiated adenocarcinomas) in order to confirm whether any specific cellular lineage differentiation occurs in UC-associated carcinogenesis. MUC2, MUC5AC, MUC1 are normally synthesized in goblet cells of gastrointestinal tract, in gastric foveolar epithelium, and in columnar and goblet cells of the colorectum, respectively. UC-CRC exhibited extensive expression of MUC2 (50-100%), MUC5AC (50-75%), and MUC1 (75%), irrespective of histological type, and MUC2+/MUC5AC+/MUC1+ was the most common mucin phenotype (4/8). Six of 8 UC-CRCs had the MUC2+ phenotype, and co-expression of MUC5AC or MUC1 was demonstrated in 5 of these. These findings were similar to those of sporadic mucinous CRCs. The present results indicate that both UC-CRCs and sporadic mucinous CRCs are predominated by cancer cells of goblet cell lineage (MUC2+) with gastric differentiation (MUC5AC+), and up-regulation of gelforming mucin MUC2 and MUC5AC would account for the frequently observed mucinous histology. This suggests that UC-associated carcinogenesis may originate from MUC5AC+ gastric metaplasia and is similar to UACL (ulcer-associated cell lineage) generated in colorectal mucosa exhibiting long-term chronic inflammation. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 1, p. 21-27, 発行日 2004-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
