{"created":"2021-03-01T06:10:09.047280+00:00","id":6254,"links":{},"metadata":{"_buckets":{"deposit":"27e69621-4391-4af8-8c05-2095c714ceb3"},"_deposit":{"id":"6254","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6254"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006254","sets":["453:456","471:537:568:589"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"21","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mucin core protein expression in ulcerative colitis-associated colorectal carcinoma (UC-CRC) has not been investigated to date. We immunohistochemically examined expression of MUC2, MUC5AC, and MUC1 mucin core proteins in 8 UC-CRCs (4 mucinous carcinomas and 4 well and/or moderately differentiated adenocarcinomas) in order to characterize their mucin phenotypes. We then compared these with sporadic colorectal carcinomas (sporadic CRCs) (30 mucinous carcinomas and 60 well and/or moderately differentiated adenocarcinomas) in order to confirm whether any specific cellular lineage differentiation occurs in UC-associated carcinogenesis. MUC2, MUC5AC, MUC1 are normally synthesized in goblet cells of gastrointestinal tract, in gastric foveolar epithelium, and in columnar and goblet cells of the colorectum, respectively. UC-CRC exhibited extensive expression of MUC2 (50-100%), MUC5AC (50-75%), and MUC1 (75%), irrespective of histological type, and MUC2+/MUC5AC+/MUC1+ was the most common mucin phenotype (4/8). Six of 8 UC-CRCs had the MUC2+ phenotype, and co-expression of MUC5AC or MUC1 was demonstrated in 5 of these. These findings were similar to those of sporadic mucinous CRCs. The present results indicate that both UC-CRCs and sporadic mucinous CRCs are predominated by cancer cells of goblet cell lineage (MUC2+) with gastric differentiation (MUC5AC+), and up-regulation of gelforming mucin MUC2 and MUC5AC would account for the frequently observed mucinous histology. This suggests that UC-associated carcinogenesis may originate from MUC5AC+ gastric metaplasia and is similar to UACL (ulcer-associated cell lineage) generated in colorectal mucosa exhibiting long-term chronic inflammation.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kanoh, Tsunehisa"}],"nameIdentifiers":[{"nameIdentifier":"51939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ajioka, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"51940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Hidenobu"}],"nameIdentifiers":[{"nameIdentifier":"51941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatakeyama, Katsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"51942","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00004267744.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004267744.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6254/files/KJ00004267744.pdf"},"version_id":"fd2b01eb-934a-49b5-a367-518d9ad25762"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ulcerative colitis","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"MUC1","subitem_subject_scheme":"Other"},{"subitem_subject":"MUC2","subitem_subject_scheme":"Other"},{"subitem_subject":"MUC5AC","subitem_subject_scheme":"Other"},{"subitem_subject":"mucin phenotype","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma"},{"subitem_title":"MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","589"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6254","relation_version_is_last":true,"title":["MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T04:31:42.042886+00:00"}