@article{oai:niigata-u.repo.nii.ac.jp:00006254,
 author = {Kanoh, Tsunehisa and Ajioka, Yoichi and Watanabe, Hidenobu and Hatakeyama, Katsuyoshi},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {Mucin core protein expression in ulcerative colitis-associated colorectal carcinoma (UC-CRC) has not been investigated to date. We immunohistochemically examined expression of MUC2, MUC5AC, and MUC1 mucin core proteins in 8 UC-CRCs (4 mucinous carcinomas and 4 well and/or moderately differentiated adenocarcinomas) in order to characterize their mucin phenotypes. We then compared these with sporadic colorectal carcinomas (sporadic CRCs) (30 mucinous carcinomas and 60 well and/or moderately differentiated adenocarcinomas) in order to confirm whether any specific cellular lineage differentiation occurs in UC-associated carcinogenesis. MUC2, MUC5AC, MUC1 are normally synthesized in goblet cells of gastrointestinal tract, in gastric foveolar epithelium, and in columnar and goblet cells of the colorectum, respectively. UC-CRC exhibited extensive expression of MUC2 (50-100%), MUC5AC (50-75%), and MUC1 (75%), irrespective of histological type, and MUC2+/MUC5AC+/MUC1+ was the most common mucin phenotype (4/8). Six of 8 UC-CRCs had the MUC2+ phenotype, and co-expression of MUC5AC or MUC1 was demonstrated in 5 of these. These findings were similar to those of sporadic mucinous CRCs. The present results indicate that both UC-CRCs and sporadic mucinous CRCs are predominated by cancer cells of goblet cell lineage (MUC2+) with gastric differentiation (MUC5AC+), and up-regulation of gelforming mucin MUC2 and MUC5AC would account for the frequently observed mucinous histology. This suggests that UC-associated carcinogenesis may originate from MUC5AC+ gastric metaplasia and is similar to UACL (ulcer-associated cell lineage) generated in colorectal mucosa exhibiting long-term chronic inflammation.},
 pages = {21--27},
 title = {MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma},
 volume = {52},
 year = {2004}
}