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Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function
http://hdl.handle.net/10191/5235
http://hdl.handle.net/10191/5235d9b157ca-9a74-40fb-929b-e82346ac4ed5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
17_0008.pdf (558.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function | |||||
| タイトル | ||||||
| タイトル | Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anxiolytic | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tandospirone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mental stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | color word conflict test | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | heart rate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | blood pressure | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Nagai, Shingo
× Nagai, Shingo× Urayama, Katsuhiro× Higuchi, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects of anxiolytics on mental stressinduced changes in heart rate and blood pressure were investigated in 54 healthy volunteers, 21-24 years of age, by double blind protocol. The mental stress induced by a computerized color word conflict test increased heart rate and systolic and diastolic blood pressure by 4.2 ± 1.0/min, 5.2 ± 1.9 mmHgand 5.9 ± 1.9 mmHg, respectively. Tandospirone citrate (p.o., 5 mg), a 5HTiA receptor agonist, did not change the resting heart rate or resting blood pressure threeh after administration, whereas metoprolol (p.o.,20 mg), a β1-adrenoceptor antagonist, gradually reduced the resting heart rate and resting systolic blood pressure. Tandospirone significantly inhibited the mental stress-induced increase in heart rate threeh after administration, just as metoprolol did. These findings suggested that a low dose of tandospirone selectively prevents the mental stress-induced changes in cardiovascular activity without affecting the resting state. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 54, 号 4, p. 103-108, 発行日 2006-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
