{"_buckets": {"deposit": "4d4e854b-f1c0-4145-9320-24f42fced2a6"}, "_deposit": {"id": "6204", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6204"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006204", "sets": ["456", "578"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "108", "bibliographicPageStart": "103", "bibliographicVolumeNumber": "54", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Effects of anxiolytics on mental stressinduced changes in heart rate and blood pressure were investigated in 54 healthy volunteers, 21-24 years of age, by double blind protocol. The mental stress induced by a computerized color word conflict test increased heart rate and systolic and diastolic blood pressure by 4.2 ± 1.0/min, 5.2 ± 1.9 mmHgand 5.9 ± 1.9 mmHg, respectively. Tandospirone citrate (p.o., 5 mg), a 5HTiA receptor agonist, did not change the resting heart rate or resting blood pressure threeh after administration, whereas metoprolol (p.o.,20 mg), a β1-adrenoceptor antagonist, gradually reduced the resting heart rate and resting systolic blood pressure. Tandospirone significantly inhibited the mental stress-induced increase in heart rate threeh after administration, just as metoprolol did. These findings suggested that a low dose of tandospirone selectively prevents the mental stress-induced changes in cardiovascular activity without affecting the resting state.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nagai, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "51633", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Urayama, Katsuhiro"}], "nameIdentifiers": [{"nameIdentifier": "51634", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "51635", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "17_0008.pdf", "filesize": [{"value": "558.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 558500.0, "url": {"label": "17_0008.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6204/files/17_0008.pdf"}, "version_id": "401390cc-90a3-49d6-832e-9b753e95e5ff"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "anxiolytic", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tandospirone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mental stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "color word conflict test", "subitem_subject_scheme": "Other"}, {"subitem_subject": "heart rate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "blood pressure", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function"}, {"subitem_title": "Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "578"], "permalink_uri": "http://hdl.handle.net/10191/5235", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-04-08"}, "publish_date": "2008-04-08", "publish_status": "0", "recid": "6204", "relation": {}, "relation_version_is_last": true, "title": ["Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function"], "weko_shared_id": null}