{"created":"2021-03-01T06:10:05.844849+00:00","id":6204,"links":{},"metadata":{"_buckets":{"deposit":"4d4e854b-f1c0-4145-9320-24f42fced2a6"},"_deposit":{"id":"6204","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6204"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006204","sets":["453:456","471:537:568:578"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"108","bibliographicPageStart":"103","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Effects of anxiolytics on mental stressinduced changes in heart rate and blood pressure were investigated in 54 healthy volunteers, 21-24 years of age, by double blind protocol. The mental stress induced by a computerized color word conflict test increased heart rate and systolic and diastolic blood pressure by 4.2 ± 1.0/min, 5.2 ± 1.9 mmHgand 5.9 ± 1.9 mmHg, respectively. Tandospirone citrate (p.o., 5 mg), a 5HTiA receptor agonist, did not change the resting heart rate or resting blood pressure threeh after administration, whereas metoprolol (p.o.,20 mg), a β1-adrenoceptor antagonist, gradually reduced the resting heart rate and resting systolic blood pressure. Tandospirone significantly inhibited the mental stress-induced increase in heart rate threeh after administration, just as metoprolol did. These findings suggested that a low dose of tandospirone selectively prevents the mental stress-induced changes in cardiovascular activity without affecting the resting state.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nagai, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"51633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Urayama, Katsuhiro"}],"nameIdentifiers":[{"nameIdentifier":"51634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"51635","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"17_0008.pdf","filesize":[{"value":"558.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17_0008.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6204/files/17_0008.pdf"},"version_id":"401390cc-90a3-49d6-832e-9b753e95e5ff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anxiolytic","subitem_subject_scheme":"Other"},{"subitem_subject":"tandospirone","subitem_subject_scheme":"Other"},{"subitem_subject":"mental stress","subitem_subject_scheme":"Other"},{"subitem_subject":"color word conflict test","subitem_subject_scheme":"Other"},{"subitem_subject":"heart rate","subitem_subject_scheme":"Other"},{"subitem_subject":"blood pressure","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function"},{"subitem_title":"Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","578"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-04-08"},"publish_date":"2008-04-08","publish_status":"0","recid":"6204","relation_version_is_last":true,"title":["Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:35.680165+00:00"}