@article{oai:niigata-u.repo.nii.ac.jp:00006204,
 author = {Nagai, Shingo and Urayama, Katsuhiro and Higuchi, Hiroshi},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {Effects of anxiolytics on mental stressinduced changes in heart rate and blood pressure were investigated in 54 healthy volunteers, 21-24 years of age, by double blind protocol. The mental stress induced by a computerized color word conflict test increased heart rate and systolic and diastolic blood pressure by 4.2 ± 1.0/min, 5.2 ± 1.9 mmHgand 5.9 ± 1.9 mmHg, respectively. Tandospirone citrate (p.o., 5 mg), a 5HTiA receptor agonist, did not change the resting heart rate or resting blood pressure threeh after administration, whereas metoprolol (p.o.,20 mg), a β1-adrenoceptor antagonist, gradually reduced the resting heart rate and resting systolic blood pressure. Tandospirone significantly inhibited the mental stress-induced increase in heart rate threeh after administration, just as metoprolol did. These findings suggested that a low dose of tandospirone selectively prevents the mental stress-induced changes in cardiovascular activity without affecting the resting state.},
 pages = {103--108},
 title = {Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function},
 volume = {54},
 year = {2006}
}