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Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance
http://hdl.handle.net/10191/5244
http://hdl.handle.net/10191/5244ac34f55a-d894-41a4-bc5d-e1e40eca0cfc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
17_0017.pdf (697.9 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance | |||||
| タイトル | ||||||
| タイトル | Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endotoxin tolerance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interferon-γ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-10 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD62Lhlgh T cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | natural regulatory Tcell | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Suzuki, Nobuaki
× Suzuki, Nobuaki× Tsukada, Hiroki× Nishibori, Takeaki× Tanabe, Yoshinari× Oota, Kyuma× Gejyo, Fumitake |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Endotoxin tolerance (ET) has been considered to develop mainly due to the hyporesponsiveness of monocytes and macrophages. Weexamined the role ofT cells in ET mice. T cells derived from ET mice showed a decreased level of interferon-γ (IFN-γ) production in comparison to those from the control mice when T cells were cocultured with peritoneal exudate cells (PEC) adherent cells from the controls or lipopolysaccharide (LPS)- injected ET mice. After anti-CD3 stimulation, IFN-γ induction by T cells derived from ET mice was significantly decreased in comparison to those from the control mice. On the other hand, interleukin-10 (IL-10) secretion by T cells derived from ET mice was higher than in those of the control mice. When T cells with a high CD62L expression (CD62Lhigh T cells) were co-cultured with PEC adherent cells, the secretion of IFN-γ tended to decrease more than when these were co-cultured with T cells with a low CD62L expression (CD62Llow T cells). Our data suggest that T cells expressing CD62Lhigh T cells in ET mice can play a suppressive role in antigen-presenting cells through their cytokine production. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 55, 号 2, p. 45-53, 発行日 2007-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Suzuki, Nobuaki, Tsukada, Hiroki, Nishibori, Takeaki, Tanabe, Yoshinari, Oota, Kyuma, Gejyo, Fumitake, 2007, Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance: Niigata University School of Medicine, 45–53 p.
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