{"created":"2021-03-01T06:10:05.408336+00:00","id":6197,"links":{},"metadata":{"_buckets":{"deposit":"2d1eecca-f29e-4808-a6ff-bbb806eb4e25"},"_deposit":{"id":"6197","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6197"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006197","sets":["453:456","471:537:568:576"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"53","bibliographicPageStart":"45","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Endotoxin tolerance (ET) has been considered to develop mainly due to the hyporesponsiveness of monocytes and macrophages. Weexamined the role ofT cells in ET mice. T cells derived from ET mice showed a decreased level of interferon-γ (IFN-γ) production in comparison to those from the control mice when T cells were cocultured with peritoneal exudate cells (PEC) adherent cells from the controls or lipopolysaccharide (LPS)- injected ET mice. After anti-CD3 stimulation, IFN-γ induction by T cells derived from ET mice was significantly decreased in comparison to those from the control mice. On the other hand, interleukin-10 (IL-10) secretion by T cells derived from ET mice was higher than in those of the control mice. When T cells with a high CD62L expression (CD62Lhigh T cells) were co-cultured with PEC adherent cells, the secretion of IFN-γ tended to decrease more than when these were co-cultured with T cells with a low CD62L expression (CD62Llow T cells). Our data suggest that T cells expressing CD62Lhigh T cells in ET mice can play a suppressive role in antigen-presenting cells through their cytokine production.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Nobuaki"}],"nameIdentifiers":[{"nameIdentifier":"51601","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukada, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"51602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishibori, Takeaki"}],"nameIdentifiers":[{"nameIdentifier":"51603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanabe, Yoshinari"}],"nameIdentifiers":[{"nameIdentifier":"51604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oota, Kyuma"}],"nameIdentifiers":[{"nameIdentifier":"51605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gejyo, Fumitake"}],"nameIdentifiers":[{"nameIdentifier":"51606","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"17_0017.pdf","filesize":[{"value":"697.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17_0017.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6197/files/17_0017.pdf"},"version_id":"9a3ff1f1-e16b-47d5-82b2-aaa9ce62f0f6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"endotoxin tolerance","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon-γ","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-10","subitem_subject_scheme":"Other"},{"subitem_subject":"CD62Lhlgh T cell","subitem_subject_scheme":"Other"},{"subitem_subject":"natural regulatory Tcell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance"},{"subitem_title":"Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","576"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-04-08"},"publish_date":"2008-04-08","publish_status":"0","recid":"6197","relation_version_is_last":true,"title":["Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:22.356840+00:00"}