@article{oai:niigata-u.repo.nii.ac.jp:00006197,
 author = {Suzuki, Nobuaki and Tsukada, Hiroki and Nishibori, Takeaki and Tanabe, Yoshinari and Oota, Kyuma and Gejyo, Fumitake},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Endotoxin tolerance (ET) has been considered to develop mainly due to the hyporesponsiveness of monocytes and macrophages. Weexamined the role ofT cells in ET mice. T cells derived from ET mice showed a decreased level of interferon-γ (IFN-γ) production in comparison to those from the control mice when T cells were cocultured with peritoneal exudate cells (PEC) adherent cells from the controls or lipopolysaccharide (LPS)- injected ET mice. After anti-CD3 stimulation, IFN-γ induction by T cells derived from ET mice was significantly decreased in comparison to those from the control mice. On the other hand, interleukin-10 (IL-10) secretion by T cells derived from ET mice was higher than in those of the control mice. When T cells with a high CD62L expression (CD62Lhigh T cells) were co-cultured with PEC adherent cells, the secretion of IFN-γ tended to decrease more than when these were co-cultured with T cells with a low CD62L expression (CD62Llow T cells). Our data suggest that T cells expressing CD62Lhigh T cells in ET mice can play a suppressive role in antigen-presenting cells through their cytokine production.},
 pages = {45--53},
 title = {Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance},
 volume = {55},
 year = {2007}
}