{"_buckets": {"deposit": "ab621d64-0536-4378-a88e-9ce90dfaaeeb"}, "_deposit": {"id": "6177", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6177"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006177"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicVolumeNumber": "58", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Objective: To evaluate the suppressive effect of two free radical scavengers, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) and Trolox\u00ae (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), on retinal ganglion cell death in transgenic Thy1-EGFP mice expressing enhanced green fluorescent protein in retinal ganglion cells. / Method: Retinal ischemia-reperfusion injury was performed on mice following intraperitoneal administration of edaravone or Trolox, and the number of retinal ganglion cells that survived ischemia/reperfusion was measured non-invasively over time using fluorescent fundus angiography. In addition, viable cells were counted in flat mount retinal specimens prepared from enucleated eyes. / Results: The fluorescence intensity at the fundus decreased steadily after transient ischemia/reperfusion. Administration of edaravone and Trolox suppressed this decrease by approximately 20% on day 7. These results were comparable with the reduction in the number of ganglion cells counted in flat mount retinal preparations. / Conclusion: Free radical scavengers effectively suppress ischemia-induced retinal ganglion cell death.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Okuyama, Shinya"}], "nameIdentifiers": [{"nameIdentifier": "51478", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Vol.58 No.1-2 Okuyama.pdf", "filesize": [{"value": "247.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 247800.0, "url": {"label": "Vol.58 No.1-2 Okuyama.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6177/files/Vol.58 No.1-2 Okuyama.pdf"}, "version_id": "c361851d-ac09-4082-a955-f8202a820dbb"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Reactive oxygen spieces", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Trolox", "subitem_subject_scheme": "Other"}, {"subitem_subject": "edaravone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RGC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glaucoma", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death"}, {"subitem_title": "Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/570"], "permalink_uri": "http://hdl.handle.net/10191/19343", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2012-08-17"}, "publish_date": "2012-08-17", "publish_status": "0", "recid": "6177", "relation": {}, "relation_version_is_last": true, "title": ["Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death"], "weko_shared_id": null}