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Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death
http://hdl.handle.net/10191/19343
http://hdl.handle.net/10191/1934326a1b433-d3ff-43c8-bbc3-6ecd04f8f69b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Vol.58 No.1-2 Okuyama.pdf (247.8 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2012-08-17 | |||||
| タイトル | ||||||
| タイトル | Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death | |||||
| タイトル | ||||||
| タイトル | Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Reactive oxygen spieces | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Trolox | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | edaravone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RGC | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glaucoma | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Okuyama, Shinya
× Okuyama, Shinya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To evaluate the suppressive effect of two free radical scavengers, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) and Trolox® (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), on retinal ganglion cell death in transgenic Thy1-EGFP mice expressing enhanced green fluorescent protein in retinal ganglion cells. / Method: Retinal ischemia-reperfusion injury was performed on mice following intraperitoneal administration of edaravone or Trolox, and the number of retinal ganglion cells that survived ischemia/reperfusion was measured non-invasively over time using fluorescent fundus angiography. In addition, viable cells were counted in flat mount retinal specimens prepared from enucleated eyes. / Results: The fluorescence intensity at the fundus decreased steadily after transient ischemia/reperfusion. Administration of edaravone and Trolox suppressed this decrease by approximately 20% on day 7. These results were comparable with the reduction in the number of ganglion cells counted in flat mount retinal preparations. / Conclusion: Free radical scavengers effectively suppress ischemia-induced retinal ganglion cell death. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 58, 号 1, 発行日 2011-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | author | |||||
