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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.58 No.1

Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death

http://hdl.handle.net/10191/19343
http://hdl.handle.net/10191/19343
26a1b433-d3ff-43c8-bbc3-6ecd04f8f69b
名前 / ファイル ライセンス アクション
Vol.58 Vol.58 No.1-2 Okuyama.pdf (247.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-08-17
タイトル
タイトル Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death
タイトル
言語 en
タイトル Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death
言語
言語 eng
キーワード
主題Scheme Other
主題 Reactive oxygen spieces
キーワード
主題Scheme Other
主題 Trolox
キーワード
主題Scheme Other
主題 edaravone
キーワード
主題Scheme Other
主題 RGC
キーワード
主題Scheme Other
主題 glaucoma
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Okuyama, Shinya

× Okuyama, Shinya

WEKO 51478

Okuyama, Shinya

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抄録
内容記述タイプ Abstract
内容記述 Objective: To evaluate the suppressive effect of two free radical scavengers, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) and Trolox® (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), on retinal ganglion cell death in transgenic Thy1-EGFP mice expressing enhanced green fluorescent protein in retinal ganglion cells. / Method: Retinal ischemia-reperfusion injury was performed on mice following intraperitoneal administration of edaravone or Trolox, and the number of retinal ganglion cells that survived ischemia/reperfusion was measured non-invasively over time using fluorescent fundus angiography. In addition, viable cells were counted in flat mount retinal specimens prepared from enucleated eyes. / Results: The fluorescence intensity at the fundus decreased steadily after transient ischemia/reperfusion. Administration of edaravone and Trolox suppressed this decrease by approximately 20% on day 7. These results were comparable with the reduction in the number of ganglion cells counted in flat mount retinal preparations. / Conclusion: Free radical scavengers effectively suppress ischemia-induced retinal ganglion cell death.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 58, 号 1, 発行日 2011-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 author
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