@article{oai:niigata-u.repo.nii.ac.jp:00006177,
 author = {Okuyama, Shinya},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Objective: To evaluate the suppressive effect of two free radical scavengers, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) and Trolox® (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), on retinal ganglion cell death in transgenic Thy1-EGFP mice expressing enhanced green fluorescent protein in retinal ganglion cells. / Method: Retinal ischemia-reperfusion injury was performed on mice following intraperitoneal administration of edaravone or Trolox, and the number of retinal ganglion cells that survived ischemia/reperfusion was measured non-invasively over time using fluorescent fundus angiography. In addition, viable cells were counted in flat mount retinal specimens prepared from enucleated eyes. / Results: The fluorescence intensity at the fundus decreased steadily after transient ischemia/reperfusion. Administration of edaravone and Trolox suppressed this decrease by approximately 20% on day 7. These results were comparable with the reduction in the number of ganglion cells counted in flat mount retinal preparations. / Conclusion: Free radical scavengers effectively suppress ischemia-induced retinal ganglion cell death.},
 title = {Protective effects of free radical scavengers on transient ischemia-induced retinal ganglion cell death},
 volume = {58},
 year = {2011}
}