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極低出生体重児の尿中副腎ホルモン分析と関連因子.
http://hdl.handle.net/10191/41907
53ba8fa9-3a4e-4ae8-b7fd-a97265fe1e30
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-05-19 | |||||
タイトル | ||||||
タイトル | 極低出生体重児の尿中副腎ホルモン分析と関連因子. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 極低出生体重児の尿中副腎ホルモン分析と関連因子. | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 尿中副腎ホルモン分析 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 液体クロマトグラフィータンデムマス法 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 新生児期ナトリウム欠乏 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 尿中ナトリウム排泄 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 低出生体重児 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | the urinary adrenal hormone analysis and associated factors in very low birth weight infants | |||||
著者 |
金子, 孝之
× 金子, 孝之 |
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著者別名 | ||||||
識別子 | ||||||
識別子 | 50744 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Kaneko, Takayuki | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 【緒言】低出生体重児は周産期環境などの影響により,成長後に高血圧を発症し易い.一方で,低出生体重児は腎尿細管機能や副腎機能の未熟性により,新生児期にナトリウム(Na)欠乏に陥り易い.Naは循環血液量や浸透圧,血圧の恒常性維持に不可欠であり,その調整には副腎ホルモンが中心的な役割を果たしている.我々は,低出生体重児の新生児期Na欠乏による副腎機能への負担が,将来の血圧上昇に繋がると考えており,本研究では新生児期の副腎機能を評価し,関連因子について検討した.【対象と方法】2010年11月から2013年3月まで新潟大学医歯学総合病院総合周産期母子医療センターNICUに入院した極低出生体重児(very low birth weight;VLBW,出生体重<1500g)を対象とした.生後2週間,1カ月時に血漿Na濃度,血漿クレアチニン濃度,尿中Na濃度(UNa),尿中Cre濃度(UCre)を測定した.液体クロマトグラフィータンデムマス法(LC-MS/MS)を用いて1カ月時の尿中副腎ホルモン(dehydroepiandrosterone;DHEA,アルドステロン,コルチゾール,コルチゾン)濃度(urinary adrenal hormone concentration;UAHC)を測定し,周産期背景やNaバランスとの関連を検討した.【結果】対象はVLBW35名(女児57.1%)で在胎期間29.97±3.14週(平均±標準偏差),出生体重1094[888-1306]g(中央値[四分位])であった.1カ月時のUAHCは尿中DHEA/Cre 3.13[1.19–7.47]μg/gCre,尿中アルドステロン/Cre 7.72[3.72–11.73]μg/gCre,尿中コルチゾール/Cre 8.80[5.03–17.32]μg/gCre,尿中コルチゾン/Cre 366.88[207.32–471.52]μg/gCreであった.1カ月時のUNa/Creと全てのUAHCに正の相関を認め,出生体重と尿中DHEA/Cre(r=-0.344,p=0.043),尿中アルドステロン/Cre(r=-0.443,p=0.008)に負の相関を認めた.【結論】LC-MS/MSを用いたVLBWの生後1カ月時のUAHCを報告した.新生児期にNa欠乏に陥り易いVLBWでは副腎機能に負担がかかり,特に出生体重が小さい児でその負担が強いことが示唆された. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 甲第4111号. 学位記番号: 新大院博(医)甲第678号. 学位授与年月日: 平成28年3月23日 | |||||
書誌情報 | 発行日 2016-03-23 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4111号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第678号 |