{"_buckets": {"deposit": "d5f09b4b-38d7-490f-9e61-2e9f9c6576c3"}, "_deposit": {"id": "5696", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5696"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005696", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "the urinary adrenal hormone analysis and associated factors in very low birth weight infants"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-03-23", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2016-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "【緒言】低出生体重児は周産期環境などの影響により，成長後に高血圧を発症し易い．一方で，低出生体重児は腎尿細管機能や副腎機能の未熟性により，新生児期にナトリウム（Na）欠乏に陥り易い．Naは循環血液量や浸透圧，血圧の恒常性維持に不可欠であり，その調整には副腎ホルモンが中心的な役割を果たしている．我々は，低出生体重児の新生児期Na欠乏による副腎機能への負担が，将来の血圧上昇に繋がると考えており，本研究では新生児期の副腎機能を評価し，関連因子について検討した．【対象と方法】2010年11月から2013年3月まで新潟大学医歯学総合病院総合周産期母子医療センターNICUに入院した極低出生体重児（very low birth weight；VLBW，出生体重＜1500g）を対象とした．生後2週間，1カ月時に血漿Na濃度，血漿クレアチニン濃度，尿中Na濃度（UNa），尿中Cre濃度（UCre）を測定した．液体クロマトグラフィータンデムマス法（LC-MS/MS）を用いて1カ月時の尿中副腎ホルモン（dehydroepiandrosterone；DHEA，アルドステロン，コルチゾール，コルチゾン）濃度（urinary adrenal hormone concentration；UAHC）を測定し，周産期背景やNaバランスとの関連を検討した．【結果】対象はVLBW35名（女児57.1%）で在胎期間29.97±3.14週（平均±標準偏差），出生体重1094[888-1306]g（中央値[四分位]）であった．1カ月時のUAHCは尿中DHEA/Cre 3.13[1.19–7.47]μg/gCre，尿中アルドステロン/Cre 7.72[3.72–11.73]μg/gCre，尿中コルチゾール/Cre 8.80[5.03–17.32]μg/gCre，尿中コルチゾン/Cre 366.88[207.32–471.52]μg/gCreであった．1カ月時のUNa/Creと全てのUAHCに正の相関を認め，出生体重と尿中DHEA/Cre（r=-0.344，p=0.043），尿中アルドステロン/Cre（r=-0.443，p=0.008）に負の相関を認めた．【結論】LC-MS/MSを用いたVLBWの生後1カ月時のUAHCを報告した．新生児期にNa欠乏に陥り易いVLBWでは副腎機能に負担がかかり，特に出生体重が小さい児でその負担が強いことが示唆された．", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士（医学）. 報告番号: 甲第4111号. 学位記番号: 新大院博（医）甲第678号. 学位授与年月日: 平成28年3月23日", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博（医）甲第678号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4111号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "50744", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kaneko, Takayuki"}]}]}, 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