{"created":"2021-03-01T06:09:33.829450+00:00","id":5696,"links":{},"metadata":{"_buckets":{"deposit":"d5f09b4b-38d7-490f-9e61-2e9f9c6576c3"},"_deposit":{"id":"5696","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5696"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005696","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"the urinary adrenal hormone analysis and associated factors in very low birth weight infants"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-23","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【緒言】低出生体重児は周産期環境などの影響により，成長後に高血圧を発症し易い．一方で，低出生体重児は腎尿細管機能や副腎機能の未熟性により，新生児期にナトリウム（Na）欠乏に陥り易い．Naは循環血液量や浸透圧，血圧の恒常性維持に不可欠であり，その調整には副腎ホルモンが中心的な役割を果たしている．我々は，低出生体重児の新生児期Na欠乏による副腎機能への負担が，将来の血圧上昇に繋がると考えており，本研究では新生児期の副腎機能を評価し，関連因子について検討した．【対象と方法】2010年11月から2013年3月まで新潟大学医歯学総合病院総合周産期母子医療センターNICUに入院した極低出生体重児（very low birth weight；VLBW，出生体重＜1500g）を対象とした．生後2週間，1カ月時に血漿Na濃度，血漿クレアチニン濃度，尿中Na濃度（UNa），尿中Cre濃度（UCre）を測定した．液体クロマトグラフィータンデムマス法（LC-MS/MS）を用いて1カ月時の尿中副腎ホルモン（dehydroepiandrosterone；DHEA，アルドステロン，コルチゾール，コルチゾン）濃度（urinary adrenal hormone concentration；UAHC）を測定し，周産期背景やNaバランスとの関連を検討した．【結果】対象はVLBW35名（女児57.1%）で在胎期間29.97±3.14週（平均±標準偏差），出生体重1094[888-1306]g（中央値[四分位]）であった．1カ月時のUAHCは尿中DHEA/Cre 3.13[1.19–7.47]μg/gCre，尿中アルドステロン/Cre 7.72[3.72–11.73]μg/gCre，尿中コルチゾール/Cre 8.80[5.03–17.32]μg/gCre，尿中コルチゾン/Cre 366.88[207.32–471.52]μg/gCreであった．1カ月時のUNa/Creと全てのUAHCに正の相関を認め，出生体重と尿中DHEA/Cre（r=-0.344，p=0.043），尿中アルドステロン/Cre（r=-0.443，p=0.008）に負の相関を認めた．【結論】LC-MS/MSを用いたVLBWの生後1カ月時のUAHCを報告した．新生児期にNa欠乏に陥り易いVLBWでは副腎機能に負担がかかり，特に出生体重が小さい児でその負担が強いことが示唆された．","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第4111号. 学位記番号: 新大院博（医）甲第678号. 学位授与年月日: 平成28年3月23日","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第678号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4111号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50744","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kaneko, Takayuki"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金子, 孝之"}],"nameIdentifiers":[{"nameIdentifier":"50743","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h27nmk678.pdf","filesize":[{"value":"461.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5696/files/h27nmk678.pdf"},"version_id":"c30d2d72-004f-412b-87fd-f2cdb21f5026"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h27nmk678_a.pdf","filesize":[{"value":"574.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5696/files/h27nmk678_a.pdf"},"version_id":"780e4dee-f186-42dd-a9c3-123d06b3399c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"尿中副腎ホルモン分析","subitem_subject_scheme":"Other"},{"subitem_subject":"液体クロマトグラフィータンデムマス法","subitem_subject_scheme":"Other"},{"subitem_subject":"新生児期ナトリウム欠乏","subitem_subject_scheme":"Other"},{"subitem_subject":"尿中ナトリウム排泄","subitem_subject_scheme":"Other"},{"subitem_subject":"低出生体重児","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"極低出生体重児の尿中副腎ホルモン分析と関連因子.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"極低出生体重児の尿中副腎ホルモン分析と関連因子."},{"subitem_title":"極低出生体重児の尿中副腎ホルモン分析と関連因子.","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-19"},"publish_date":"2016-05-19","publish_status":"0","recid":"5696","relation_version_is_last":true,"title":["極低出生体重児の尿中副腎ホルモン分析と関連因子."],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:38:50.868081+00:00"}