{"_buckets": {"deposit": "ee9d3a3a-ed61-4360-a6a7-d2f681c9e917"}, "_deposit": {"id": "33822", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "33822"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00033822", "sets": ["456", "1999"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Bacteriological Research of Non-tuberculous Mycobacteriosis"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "108", "bibliographicPageStart": "103", "bibliographicVolumeNumber": "133", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "NIIGATA MEDICAL JOURNAL", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "代表的な非結核性抗酸菌であるMycobacterium avium-intracellulare complex (MAC 菌）は，環境常在菌・人獣共通病原体である点で結核菌と大きく異なる．近年，肺MAC症は中高年女性を中心に現在急増している（罹患率15以上/10万人年）にもかかわらず，菌の増殖・生存機構といった基本的な細菌学的性状が未解明であるため，感染対策ならびに新規治療法の開拓が阻まれている．当教室では， MAC菌が低酸素・富栄養条件でバイオフィルムを形成することを解明した．さらに，トランスポゾン変異導入システムと次世代シーケンサーを利用した解析により，バイオフィルム形成必須因子として，糖質・脂質代謝経路の再構築，ストレス応答性の転写開始因子，ならびにプロテアソーム系を構成する遺伝子が挙がってきた.MAC菌の細菌学研究により，新規薬剤標的発見などの臨床に還元できる成果を目指したい．", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "57500", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "TATEISHI, Yoshitaka"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "立石, 善隆"}], "nameIdentifiers": [{"nameIdentifier": "57495", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-04-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "133（3）_103_1.pdf", "filesize": [{"value": "3.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3700000.0, "url": {"label": "133（3）_103_1", "url": "https://niigata-u.repo.nii.ac.jp/record/33822/files/133（3）_103_1.pdf"}, "version_id": "bb93e289-5986-48e6-a1b2-836a0fcdf071"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "非結核性抗酸菌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mycobacterium avium", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mycobacterium intracellulare", "subitem_subject_scheme": "Other"}, {"subitem_subject": "バイオフィルム", "subitem_subject_scheme": "Other"}, {"subitem_subject": "トランスポゾンーシーケンシング", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "1 細菌学からみた非結核性抗酸菌症の研究 (シンポジウム 感染症研究の新たな展開, 第734回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "1 細菌学からみた非結核性抗酸菌症の研究 (シンポジウム 感染症研究の新たな展開, 第734回新潟医学会)"}, {"subitem_title": "Bacteriological Research of Non-tuberculous Mycobacteriosis", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1999"], "permalink_uri": "http://hdl.handle.net/10191/00051644", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-04-24"}, "publish_date": "2020-04-24", "publish_status": "0", "recid": "33822", "relation": {}, "relation_version_is_last": true, "title": ["1 細菌学からみた非結核性抗酸菌症の研究 (シンポジウム 感染症研究の新たな展開, 第734回新潟医学会)"], "weko_shared_id": 2}