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Bacteriological Research of Non-tuberculous Mycobacteriosis
http://hdl.handle.net/10191/00051644
d804283c-a20d-4643-b014-cd9b92bc0dec
| 名前 / ファイル | ライセンス | アクション | |
|---|---|---|---|
133（3）_103_1 (3.7 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-24 | |||||
| タイトル | ||||||
| タイトル | 1 細菌学からみた非結核性抗酸菌症の研究 (シンポジウム 感染症研究の新たな展開, 第734回新潟医学会) | |||||
| タイトル | ||||||
| 言語 | en | |||||
| タイトル | Bacteriological Research of Non-tuberculous Mycobacteriosis | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 非結核性抗酸菌 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mycobacterium avium | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mycobacterium intracellulare | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | バイオフィルム | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | トランスポゾンーシーケンシング | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Bacteriological Research of Non-tuberculous Mycobacteriosis | |||||
| 著者 |
立石, 善隆
× 立石, 善隆 |
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| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 57500 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | TATEISHI, Yoshitaka | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 代表的な非結核性抗酸菌であるMycobacterium avium-intracellulare complex (MAC 菌）は，環境常在菌・人獣共通病原体である点で結核菌と大きく異なる．近年，肺MAC症は中高年女性を中心に現在急増している（罹患率15以上/10万人年）にもかかわらず，菌の増殖・生存機構といった基本的な細菌学的性状が未解明であるため，感染対策ならびに新規治療法の開拓が阻まれている．当教室では， MAC菌が低酸素・富栄養条件でバイオフィルムを形成することを解明した．さらに，トランスポゾン変異導入システムと次世代シーケンサーを利用した解析により，バイオフィルム形成必須因子として，糖質・脂質代謝経路の再構築，ストレス応答性の転写開始因子，ならびにプロテアソーム系を構成する遺伝子が挙がってきた.MAC菌の細菌学研究により，新規薬剤標的発見などの臨床に還元できる成果を目指したい． | |||||
| 書誌情報 |
新潟医学会雑誌 en : NIIGATA MEDICAL JOURNAL 巻 133, 号 3, p. 103-108, 発行日 2019-03 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
