{"created":"2021-03-01T06:40:16.237754+00:00","id":33822,"links":{},"metadata":{"_buckets":{"deposit":"ee9d3a3a-ed61-4360-a6a7-d2f681c9e917"},"_deposit":{"id":"33822","owners":[],"pid":{"revision_id":0,"type":"depid","value":"33822"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00033822","sets":["453:456","471:537:538:1999"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Bacteriological Research of Non-tuberculous Mycobacteriosis"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"108","bibliographicPageStart":"103","bibliographicVolumeNumber":"133","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"NIIGATA MEDICAL JOURNAL","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"代表的な非結核性抗酸菌であるMycobacterium avium-intracellulare complex (MAC 菌）は，環境常在菌・人獣共通病原体である点で結核菌と大きく異なる．近年，肺MAC症は中高年女性を中心に現在急増している（罹患率15以上/10万人年）にもかかわらず，菌の増殖・生存機構といった基本的な細菌学的性状が未解明であるため，感染対策ならびに新規治療法の開拓が阻まれている．当教室では， MAC菌が低酸素・富栄養条件でバイオフィルムを形成することを解明した．さらに，トランスポゾン変異導入システムと次世代シーケンサーを利用した解析により，バイオフィルム形成必須因子として，糖質・脂質代謝経路の再構築，ストレス応答性の転写開始因子，ならびにプロテアソーム系を構成する遺伝子が挙がってきた.MAC菌の細菌学研究により，新規薬剤標的発見などの臨床に還元できる成果を目指したい．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"57500","nameIdentifierScheme":"WEKO"}],"names":[{"name":"TATEISHI, Yoshitaka"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"立石, 善隆"}],"nameIdentifiers":[{"nameIdentifier":"57495","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-24"}],"displaytype":"detail","filename":"133（3）_103_1.pdf","filesize":[{"value":"3.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"133（3）_103_1","url":"https://niigata-u.repo.nii.ac.jp/record/33822/files/133（3）_103_1.pdf"},"version_id":"bb93e289-5986-48e6-a1b2-836a0fcdf071"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"非結核性抗酸菌","subitem_subject_scheme":"Other"},{"subitem_subject":"Mycobacterium avium","subitem_subject_scheme":"Other"},{"subitem_subject":"Mycobacterium intracellulare","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオフィルム","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスポゾンーシーケンシング","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"1 細菌学からみた非結核性抗酸菌症の研究 (シンポジウム 感染症研究の新たな展開, 第734回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1 細菌学からみた非結核性抗酸菌症の研究 (シンポジウム 感染症研究の新たな展開, 第734回新潟医学会)"},{"subitem_title":"Bacteriological Research of Non-tuberculous Mycobacteriosis","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1999"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"33822","relation_version_is_last":true,"title":["1 細菌学からみた非結核性抗酸菌症の研究 (シンポジウム 感染症研究の新たな展開, 第734回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:04:04.761671+00:00"}