{"_buckets": {"deposit": "92f1c469-5fe3-4375-94b4-4feb072ba774"}, "_deposit": {"id": "28578", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28578"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00028578"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Identification of IFN-\u03b3 production and cytotoxicity in WT1 tetramer+ T cells generated by mixed lymphocyte peptide culture in WT1 peptide immunized persons"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "65", "bibliographicPageStart": "57", "bibliographicVolumeNumber": "11", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u4fdd\u5065\u5b66\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u4fdd\u5065\u5b66\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u6297\u816b\u760d\u514d\u75ab\u7642\u6cd5\u65bd\u884c\u4f8b\u306b\u304a\u3051\u308b\u6cbb\u7642\u52b9\u679c\u3092\u5224\u5b9a\u3059\u308b\u305f\u3081\u306b\uff0cin vitro\u3067\u57f9\u990a\u3055\u308c\u305f\u816b\u760d\u6297\u539f\u7279\u7570\u7684\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\uff08CTL\uff09\u304c\u7279\u7570\u7684\u306b\u6297\u539f\u3092\u8a8d\u8b58\u3057\uff0c\u7d30\u80de\u50b7\u5bb3\u6a5f\u80fd\u3092\u6709\u3059\u308b\u304b\u8abf\u3079\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002\u672c\u691c\u8a0e\u3067\u306f\uff0cin vivo\u306b\u5b58\u5728\u3059\u308bWT1\u7279\u7570\u7684CTL\u3092\u6df7\u5408\u30ea\u30f3\u30d1\u7403\u30da\u30d7\u30c1\u30c9\u57f9\u990a\uff08mixed lymphocyte peptide culture; MLPC\uff09\u306b\u3088\u308ain vitro\u3067\u5897\u5e45\u3057\uff0cWT1\u7279\u7570\u7684CTL\u306e\u6a5f\u80fd\u89e3\u6790\u3092\u884c\u3063\u305f\u3002in vitro\u3067\u8a98\u5c0e\u3055\u308c\u305fWT1\u7279\u7570\u7684CTL\u306fWT1\u6297\u539f\u7279\u7570\u7684\u306bIFN-\u03b3\u3092\u5408\u6210\u3057\uff0c\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\uff0cWT1\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u65bd\u884c\u4f8b\u306e\u672b\u68a2\u8840\u4e2d\u306b\u306fIFN-\u03b3\u306e\u7523\u751f\u80fd\u3068\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u3092\u6301\u3064WT1\u7279\u7570\u7684CTL\u304c\u5b58\u5728\u3057\uff0c\u3053\u308c\u3089\u306eCTL\u306f\u3055\u3089\u306a\u308bWT1\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308a\u5897\u5e45\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002", "subitem_description_type": "Abstract"}, {"subitem_description": "Although the frequencies of cytotoxic T lymphocytes\uff08CTLs\uff09in peripheral blood\uff08PB\uff09can be evaluated by mixed lymphocyte peptide culture\uff08MLPC\uff09, the function of tetramer+ CD8+ T cells induced by MLPC has not been studied extensively yet. Therefore, we aimed to explore the function of tetramer+ CD8+ T cells generated by MLPC. We confirmed that population of tetramer positive cells in MLPC produced IFN-\u03b3 by recall stimulation, using intracellular cytokine staining. This study showed that WT1 positive cells, which were induced by MLPC, have function of producing IFN-\u03b3 and killing target cells. The present findings suggest that WT1 peptide immunized persons hold WT1 specific CTLs and IFN-\u03b3 production and cytotoxicity in CTLs could be enhanced by further WT1 peptide vaccination.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "164533", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Oiwa, Eri"}]}, {"nameIdentifiers": [{"nameIdentifier": "164534", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Narita, Miwako"}]}, {"nameIdentifiers": [{"nameIdentifier": "164535", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Iwaya, Shunpei"}]}, {"nameIdentifiers": [{"nameIdentifier": "164536", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nishizawa, Yoshinori"}]}, {"nameIdentifiers": [{"nameIdentifier": "164537", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Uchiyama, Takayoshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "164538", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Iwabuchi, Minami"}]}, {"nameIdentifiers": [{"nameIdentifier": "164539", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takahashi, Masuhiro"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u5927\u5b66\u533b\u5b66\u90e8\u4fdd\u5065\u5b66\u79d1"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12680484", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "21884617", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5927\u5ca9, \u6075\u7406"}], "nameIdentifiers": [{"nameIdentifier": "164526", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u6210\u7530, \u7f8e\u548c\u5b50"}], "nameIdentifiers": [{"nameIdentifier": "164527", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u5ca9\u8c37, \u4fca\u5e73"}], "nameIdentifiers": [{"nameIdentifier": "164528", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u897f\u6fa4, \u5e79\u5247"}], "nameIdentifiers": [{"nameIdentifier": "164529", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u5185\u5c71, \u5b5d\u7531"}], "nameIdentifiers": [{"nameIdentifier": "164530", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u5ca9\u6e15, \u5357"}], "nameIdentifiers": [{"nameIdentifier": "164531", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u9ad8\u6a4b, \u76ca\u5ee3"}], "nameIdentifiers": [{"nameIdentifier": "164532", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "11(1)_57-65.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2100000.0, "url": {"label": "11(1)_57-65.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/28578/files/11(1)_57-65.pdf"}, "version_id": "92c09584-5e1a-4957-8a27-31bb8bb8c00d"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "WT1\u6297\u539f", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de \uff08CTL\uff09", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IFN-\u03b3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027", "subitem_subject_scheme": "Other"}, {"subitem_subject": "WT1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytotoxic T lymphocyte \uff08CTL\uff09", "subitem_subject_scheme": "Other"}, {"subitem_subject": "peptide vaccine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytotoxicity", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "WT1\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u65bd\u884c\u75c7\u4f8b\u306b\u304a\u3051\u308bWT1\u7279\u7570\u7684\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\u306e\u691c\u51fa\u53ca\u3073\u305d\u306eIFN-\u03b3\u7523\u751f\u80fd\u3068\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u306e\u540c\u5b9a", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "WT1\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u65bd\u884c\u75c7\u4f8b\u306b\u304a\u3051\u308bWT1\u7279\u7570\u7684\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\u306e\u691c\u51fa\u53ca\u3073\u305d\u306eIFN-\u03b3\u7523\u751f\u80fd\u3068\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u306e\u540c\u5b9a"}, {"subitem_title": "WT1\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u65bd\u884c\u75c7\u4f8b\u306b\u304a\u3051\u308bWT1\u7279\u7570\u7684\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\u306e\u691c\u51fa\u53ca\u3073\u305d\u306eIFN-\u03b3\u7523\u751f\u80fd\u3068\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u306e\u540c\u5b9a", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "506/1624/1625/1630"], "permalink_uri": "http://hdl.handle.net/10191/38934", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-02-29"}, "publish_date": "2016-02-29", "publish_status": "0", "recid": "28578", "relation": {}, "relation_version_is_last": true, "title": ["WT1\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u65bd\u884c\u75c7\u4f8b\u306b\u304a\u3051\u308bWT1\u7279\u7570\u7684\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\u306e\u691c\u51fa\u53ca\u3073\u305d\u306eIFN-\u03b3\u7523\u751f\u80fd\u3068\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u306e\u540c\u5b9a"], "weko_shared_id": null}