WEKO3
アイテム
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WT1ペプチドワクチン施行症例におけるWT1特異的細胞傷害性T細胞の検出及びそのIFN-γ産生能と細胞傷害活性の同定
http://hdl.handle.net/10191/38934
http://hdl.handle.net/10191/38934a5b7bc81-6221-4ed3-b6d6-4cb1f849ac42
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-29 | |||||
タイトル | ||||||
タイトル | WT1ペプチドワクチン施行症例におけるWT1特異的細胞傷害性T細胞の検出及びそのIFN-γ産生能と細胞傷害活性の同定 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | WT1ペプチドワクチン施行症例におけるWT1特異的細胞傷害性T細胞の検出及びそのIFN-γ産生能と細胞傷害活性の同定 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | WT1抗原 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 細胞傷害性T細胞 (CTL) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ペプチドワクチン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IFN-γ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 細胞傷害活性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | WT1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytotoxic T lymphocyte (CTL) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peptide vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytotoxicity | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Identification of IFN-γ production and cytotoxicity in WT1 tetramer+ T cells generated by mixed lymphocyte peptide culture in WT1 peptide immunized persons | |||||
著者 |
大岩, 恵理
× 大岩, 恵理× 成田, 美和子× 岩谷, 俊平× 西澤, 幹則× 内山, 孝由× 岩渕, 南× 高橋, 益廣 |
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著者別名 | ||||||
識別子 | 164533 | |||||
識別子Scheme | WEKO | |||||
姓名 | Oiwa, Eri | |||||
著者別名 | ||||||
識別子 | 164534 | |||||
識別子Scheme | WEKO | |||||
姓名 | Narita, Miwako | |||||
著者別名 | ||||||
識別子 | 164535 | |||||
識別子Scheme | WEKO | |||||
姓名 | Iwaya, Shunpei | |||||
著者別名 | ||||||
識別子 | 164536 | |||||
識別子Scheme | WEKO | |||||
姓名 | Nishizawa, Yoshinori | |||||
著者別名 | ||||||
識別子 | 164537 | |||||
識別子Scheme | WEKO | |||||
姓名 | Uchiyama, Takayoshi | |||||
著者別名 | ||||||
識別子 | 164538 | |||||
識別子Scheme | WEKO | |||||
姓名 | Iwabuchi, Minami | |||||
著者別名 | ||||||
識別子 | 164539 | |||||
識別子Scheme | WEKO | |||||
姓名 | Takahashi, Masuhiro | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 抗腫瘍免疫療法施行例における治療効果を判定するために,in vitroで培養された腫瘍抗原特異的細胞傷害性T細胞(CTL)が特異的に抗原を認識し,細胞傷害機能を有するか調べることを目的とした。本検討では,in vivoに存在するWT1特異的CTLを混合リンパ球ペプチド培養(mixed lymphocyte peptide culture; MLPC)によりin vitroで増幅し,WT1特異的CTLの機能解析を行った。in vitroで誘導されたWT1特異的CTLはWT1抗原特異的にIFN-γを合成し,細胞傷害活性を有することが確認された。以上のことから,WT1ペプチドワクチン施行例の末梢血中にはIFN-γの産生能と細胞傷害活性を持つWT1特異的CTLが存在し,これらのCTLはさらなるWT1ペプチドワクチンにより増幅されると考えられた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although the frequencies of cytotoxic T lymphocytes(CTLs)in peripheral blood(PB)can be evaluated by mixed lymphocyte peptide culture(MLPC), the function of tetramer+ CD8+ T cells induced by MLPC has not been studied extensively yet. Therefore, we aimed to explore the function of tetramer+ CD8+ T cells generated by MLPC. We confirmed that population of tetramer positive cells in MLPC produced IFN-γ by recall stimulation, using intracellular cytokine staining. This study showed that WT1 positive cells, which were induced by MLPC, have function of producing IFN-γ and killing target cells. The present findings suggest that WT1 peptide immunized persons hold WT1 specific CTLs and IFN-γ production and cytotoxicity in CTLs could be enhanced by further WT1 peptide vaccination. | |||||
書誌情報 |
新潟大学保健学雑誌 en : 新潟大学保健学雑誌 巻 11, 号 1, p. 57-65, 発行日 2014-03 |
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出版者 | ||||||
出版者 | 新潟大学医学部保健学科 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 21884617 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12680484 | |||||
著者版フラグ | ||||||
値 | publisher |