{"created":"2021-03-01T06:34:24.305940+00:00","id":28578,"links":{},"metadata":{"_buckets":{"deposit":"92f1c469-5fe3-4375-94b4-4feb072ba774"},"_deposit":{"id":"28578","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28578"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00028578"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"Identification of IFN-\u03b3 production and cytotoxicity in WT1 tetramer+ T cells generated by mixed lymphocyte peptide culture in WT1 peptide immunized persons"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"65","bibliographicPageStart":"57","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u5927\u5b66\u4fdd\u5065\u5b66\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u5927\u5b66\u4fdd\u5065\u5b66\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"\u6297\u816b\u760d\u514d\u75ab\u7642\u6cd5\u65bd\u884c\u4f8b\u306b\u304a\u3051\u308b\u6cbb\u7642\u52b9\u679c\u3092\u5224\u5b9a\u3059\u308b\u305f\u3081\u306b\uff0cin vitro\u3067\u57f9\u990a\u3055\u308c\u305f\u816b\u760d\u6297\u539f\u7279\u7570\u7684\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\uff08CTL\uff09\u304c\u7279\u7570\u7684\u306b\u6297\u539f\u3092\u8a8d\u8b58\u3057\uff0c\u7d30\u80de\u50b7\u5bb3\u6a5f\u80fd\u3092\u6709\u3059\u308b\u304b\u8abf\u3079\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002\u672c\u691c\u8a0e\u3067\u306f\uff0cin vivo\u306b\u5b58\u5728\u3059\u308bWT1\u7279\u7570\u7684CTL\u3092\u6df7\u5408\u30ea\u30f3\u30d1\u7403\u30da\u30d7\u30c1\u30c9\u57f9\u990a\uff08mixed lymphocyte peptide culture; MLPC\uff09\u306b\u3088\u308ain vitro\u3067\u5897\u5e45\u3057\uff0cWT1\u7279\u7570\u7684CTL\u306e\u6a5f\u80fd\u89e3\u6790\u3092\u884c\u3063\u305f\u3002in vitro\u3067\u8a98\u5c0e\u3055\u308c\u305fWT1\u7279\u7570\u7684CTL\u306fWT1\u6297\u539f\u7279\u7570\u7684\u306bIFN-\u03b3\u3092\u5408\u6210\u3057\uff0c\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\uff0cWT1\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u65bd\u884c\u4f8b\u306e\u672b\u68a2\u8840\u4e2d\u306b\u306fIFN-\u03b3\u306e\u7523\u751f\u80fd\u3068\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u3092\u6301\u3064WT1\u7279\u7570\u7684CTL\u304c\u5b58\u5728\u3057\uff0c\u3053\u308c\u3089\u306eCTL\u306f\u3055\u3089\u306a\u308bWT1\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308a\u5897\u5e45\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002","subitem_description_type":"Abstract"},{"subitem_description":"Although the frequencies of cytotoxic T lymphocytes\uff08CTLs\uff09in peripheral blood\uff08PB\uff09can be evaluated by mixed lymphocyte peptide culture\uff08MLPC\uff09, the function of tetramer+ CD8+ T cells induced by MLPC has not been studied extensively yet. Therefore, we aimed to explore the function of tetramer+ CD8+ T cells generated by MLPC. We confirmed that population of tetramer positive cells in MLPC produced IFN-\u03b3 by recall stimulation, using intracellular cytokine staining. This study showed that WT1 positive cells, which were induced by MLPC, have function of producing IFN-\u03b3 and killing target cells. The present findings suggest that WT1 peptide immunized persons hold WT1 specific CTLs and IFN-\u03b3 production and cytotoxicity in CTLs could be enhanced by further WT1 peptide vaccination.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"164533","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Oiwa, Eri"}]},{"nameIdentifiers":[{"nameIdentifier":"164534","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Narita, Miwako"}]},{"nameIdentifiers":[{"nameIdentifier":"164535","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Iwaya, Shunpei"}]},{"nameIdentifiers":[{"nameIdentifier":"164536","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nishizawa, Yoshinori"}]},{"nameIdentifiers":[{"nameIdentifier":"164537","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Uchiyama, Takayoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"164538","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Iwabuchi, Minami"}]},{"nameIdentifiers":[{"nameIdentifier":"164539","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takahashi, 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\uff08CTL\uff09","subitem_subject_scheme":"Other"},{"subitem_subject":"\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-\u03b3","subitem_subject_scheme":"Other"},{"subitem_subject":"\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027","subitem_subject_scheme":"Other"},{"subitem_subject":"WT1","subitem_subject_scheme":"Other"},{"subitem_subject":"cytotoxic T lymphocyte \uff08CTL\uff09","subitem_subject_scheme":"Other"},{"subitem_subject":"peptide vaccine","subitem_subject_scheme":"Other"},{"subitem_subject":"cytotoxicity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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