{"_buckets": {"deposit": "b899d1a0-c57c-4c05-9f72-ec8082189bb4"}, "_deposit": {"id": "22909", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22909"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00022909", "sets": ["456", "1210"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "The Role of IL-1 and IL-2 for T cell Activation to Allo-MHC antigen(Recent Advances in Research on the Cell Growth Factors)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "353", "bibliographicPageStart": "350", "bibliographicVolumeNumber": "103", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Interleukin 1 (IL-1) is normally produced by activated MΦ and has a wide range of biological activities. One of these activity is the capacity to induce the IL-2 production of T cells. Interleukin 2 (IL-2), produced by activated T cells, induces the proliferation and differentiation on T and B cells. In this report, the signal requirement for the activation of T cells in C57BL/6 mice was examined in in vitro responses to mutant MHC class I antigen (H-2K^\u003cbm1\u003e). From our observations, activation of T cells responding to MHC class I antigen could be explained as follows. Lyt 2^+ T cells recognize directly the mutant MHC class I antigen and then IL-1 receptor (IL-1R) and IL-2 receptor (IL-2R) appear on the T cells. Accessory cells secrete IL-1 upon the binding of T cells. The secreted IL-1 may bind IL-1R on the responding T cells and induce production of IL-2, which binds to IL-2R. Thus, T cell proliferation and CTL (cytotoxic T lymphocyte) generation will proceed autonomously.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "138466", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Watanabe, Hisami"}]}, {"nameIdentifiers": [{"nameIdentifier": "138467", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fujiwara, Michio"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "渡部, 久実"}], "nameIdentifiers": [{"nameIdentifier": "138464", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤原, 道夫"}], "nameIdentifiers": [{"nameIdentifier": "138465", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "103(5)_350-353.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "103(5)_350-353.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22909/files/103(5)_350-353.pdf"}, "version_id": "004d1243-9a24-4596-a84b-a74917af2ba2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "T cell activation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Allo-MHC antigen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Accessory cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T細胞活性化", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アロMHC抗原", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アクセサリー細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "インターロイキン1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "インターロイキン2", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)"}, {"subitem_title": "3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1210"], "permalink_uri": "http://hdl.handle.net/10191/41251", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-04-11"}, "publish_date": "2016-04-11", "publish_status": "0", "recid": "22909", "relation": {}, "relation_version_is_last": true, "title": ["3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)"], "weko_shared_id": null}