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3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)
http://hdl.handle.net/10191/41251
http://hdl.handle.net/10191/412517036c09e-4fc1-4129-879b-c56051820408
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-04-11 | |||||
タイトル | ||||||
タイトル | 3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cell activation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Allo-MHC antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Accessory cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T細胞活性化 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アロMHC抗原 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アクセサリー細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インターロイキン1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インターロイキン2 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | The Role of IL-1 and IL-2 for T cell Activation to Allo-MHC antigen(Recent Advances in Research on the Cell Growth Factors) | |||||
著者 |
渡部, 久実
× 渡部, 久実× 藤原, 道夫 |
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著者別名 | ||||||
識別子 | 138466 | |||||
識別子Scheme | WEKO | |||||
姓名 | Watanabe, Hisami | |||||
著者別名 | ||||||
識別子 | 138467 | |||||
識別子Scheme | WEKO | |||||
姓名 | Fujiwara, Michio | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interleukin 1 (IL-1) is normally produced by activated MΦ and has a wide range of biological activities. One of these activity is the capacity to induce the IL-2 production of T cells. Interleukin 2 (IL-2), produced by activated T cells, induces the proliferation and differentiation on T and B cells. In this report, the signal requirement for the activation of T cells in C57BL/6 mice was examined in in vitro responses to mutant MHC class I antigen (H-2K^<bm1>). From our observations, activation of T cells responding to MHC class I antigen could be explained as follows. Lyt 2^+ T cells recognize directly the mutant MHC class I antigen and then IL-1 receptor (IL-1R) and IL-2 receptor (IL-2R) appear on the T cells. Accessory cells secrete IL-1 upon the binding of T cells. The secreted IL-1 may bind IL-1R on the responding T cells and induce production of IL-2, which binds to IL-2R. Thus, T cell proliferation and CTL (cytotoxic T lymphocyte) generation will proceed autonomously. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 103, 号 5, p. 350-353, 発行日 1989-05 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |