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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第103巻第5号

3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)

http://hdl.handle.net/10191/41251
http://hdl.handle.net/10191/41251
7036c09e-4fc1-4129-879b-c56051820408
名前 / ファイル ライセンス アクション
103(5)_350-353.pdf 103(5)_350-353.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-04-11
タイトル
タイトル 3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)
タイトル
言語 en
タイトル 3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 T cell activation
キーワード
主題Scheme Other
主題 Allo-MHC antigen
キーワード
主題Scheme Other
主題 Accessory cells
キーワード
主題Scheme Other
主題 IL-1
キーワード
主題Scheme Other
主題 IL-2
キーワード
主題Scheme Other
主題 T細胞活性化
キーワード
主題Scheme Other
主題 アロMHC抗原
キーワード
主題Scheme Other
主題 アクセサリー細胞
キーワード
主題Scheme Other
主題 インターロイキン1
キーワード
主題Scheme Other
主題 インターロイキン2
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル The Role of IL-1 and IL-2 for T cell Activation to Allo-MHC antigen(Recent Advances in Research on the Cell Growth Factors)
著者 渡部, 久実

× 渡部, 久実

WEKO 138464

渡部, 久実

Search repository
藤原, 道夫

× 藤原, 道夫

WEKO 138465

藤原, 道夫

Search repository
著者別名
識別子 138466
識別子Scheme WEKO
姓名 Watanabe, Hisami
著者別名
識別子 138467
識別子Scheme WEKO
姓名 Fujiwara, Michio
抄録
内容記述タイプ Abstract
内容記述 Interleukin 1 (IL-1) is normally produced by activated MΦ and has a wide range of biological activities. One of these activity is the capacity to induce the IL-2 production of T cells. Interleukin 2 (IL-2), produced by activated T cells, induces the proliferation and differentiation on T and B cells. In this report, the signal requirement for the activation of T cells in C57BL/6 mice was examined in in vitro responses to mutant MHC class I antigen (H-2K^<bm1>). From our observations, activation of T cells responding to MHC class I antigen could be explained as follows. Lyt 2^+ T cells recognize directly the mutant MHC class I antigen and then IL-1 receptor (IL-1R) and IL-2 receptor (IL-2R) appear on the T cells. Accessory cells secrete IL-1 upon the binding of T cells. The secreted IL-1 may bind IL-1R on the responding T cells and induce production of IL-2, which binds to IL-2R. Thus, T cell proliferation and CTL (cytotoxic T lymphocyte) generation will proceed autonomously.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 103, 号 5, p. 350-353, 発行日 1989-05
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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