{"_buckets": {"deposit": "b899d1a0-c57c-4c05-9f72-ec8082189bb4"}, "_deposit": {"id": "22909", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22909"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00022909"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "The Role of IL-1 and IL-2 for T cell Activation to Allo-MHC antigen(Recent Advances in Research on the Cell Growth Factors)"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "353", "bibliographicPageStart": "350", "bibliographicVolumeNumber": "103", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Interleukin 1 (IL-1) is normally produced by activated M\u03a6 and has a wide range of biological activities. One of these activity is the capacity to induce the IL-2 production of T cells. Interleukin 2 (IL-2), produced by activated T cells, induces the proliferation and differentiation on T and B cells. In this report, the signal requirement for the activation of T cells in C57BL/6 mice was examined in in vitro responses to mutant MHC class I antigen (H-2K^\u003cbm1\u003e). From our observations, activation of T cells responding to MHC class I antigen could be explained as follows. Lyt 2^+ T cells recognize directly the mutant MHC class I antigen and then IL-1 receptor (IL-1R) and IL-2 receptor (IL-2R) appear on the T cells. Accessory cells secrete IL-1 upon the binding of T cells. The secreted IL-1 may bind IL-1R on the responding T cells and induce production of IL-2, which binds to IL-2R. Thus, T cell proliferation and CTL (cytotoxic T lymphocyte) generation will proceed autonomously.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "138466", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Watanabe, Hisami"}]}, {"nameIdentifiers": [{"nameIdentifier": "138467", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fujiwara, Michio"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": 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"license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "103(5)_350-353.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22909/files/103(5)_350-353.pdf"}, "version_id": "004d1243-9a24-4596-a84b-a74917af2ba2"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "T cell activation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Allo-MHC antigen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Accessory cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T\u7d30\u80de\u6d3b\u6027\u5316", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a2\u30edMHC\u6297\u539f", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a2\u30af\u30bb\u30b5\u30ea\u30fc\u7d30\u80de", "subitem_subject_scheme": "Other"}, {"subitem_subject": 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