{"created":"2021-03-01T06:28:06.704782+00:00","id":22909,"links":{},"metadata":{"_buckets":{"deposit":"b899d1a0-c57c-4c05-9f72-ec8082189bb4"},"_deposit":{"id":"22909","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22909"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00022909","sets":["453:456","471:537:538:1210"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Role of IL-1 and IL-2 for T cell Activation to Allo-MHC antigen(Recent Advances in Research on the Cell Growth Factors)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"353","bibliographicPageStart":"350","bibliographicVolumeNumber":"103","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interleukin 1 (IL-1) is normally produced by activated MΦ and has a wide range of biological activities. One of these activity is the capacity to induce the IL-2 production of T cells. Interleukin 2 (IL-2), produced by activated T cells, induces the proliferation and differentiation on T and B cells. In this report, the signal requirement for the activation of T cells in C57BL/6 mice was examined in in vitro responses to mutant MHC class I antigen (H-2K^<bm1>). From our observations, activation of T cells responding to MHC class I antigen could be explained as follows. Lyt 2^+ T cells recognize directly the mutant MHC class I antigen and then IL-1 receptor (IL-1R) and IL-2 receptor (IL-2R) appear on the T cells. Accessory cells secrete IL-1 upon the binding of T cells. The secreted IL-1 may bind IL-1R on the responding T cells and induce production of IL-2, which binds to IL-2R. Thus, T cell proliferation and CTL (cytotoxic T lymphocyte) generation will proceed autonomously.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"138466","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Hisami"}]},{"nameIdentifiers":[{"nameIdentifier":"138467","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujiwara, Michio"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡部, 久実"}],"nameIdentifiers":[{"nameIdentifier":"138464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原, 道夫"}],"nameIdentifiers":[{"nameIdentifier":"138465","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"103(5)_350-353.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"103(5)_350-353.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/22909/files/103(5)_350-353.pdf"},"version_id":"004d1243-9a24-4596-a84b-a74917af2ba2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"T cell activation","subitem_subject_scheme":"Other"},{"subitem_subject":"Allo-MHC antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"Accessory cells","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-1","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-2","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞活性化","subitem_subject_scheme":"Other"},{"subitem_subject":"アロMHC抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"アクセサリー細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"インターロイキン1","subitem_subject_scheme":"Other"},{"subitem_subject":"インターロイキン2","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)"},{"subitem_title":"3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1210"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-04-11"},"publish_date":"2016-04-11","publish_status":"0","recid":"22909","relation_version_is_last":true,"title":["3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:53:09.128358+00:00"}