@article{oai:niigata-u.repo.nii.ac.jp:00022909, author = {渡部, 久実 and 藤原, 道夫}, issue = {5}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {May}, note = {Interleukin 1 (IL-1) is normally produced by activated MΦ and has a wide range of biological activities. One of these activity is the capacity to induce the IL-2 production of T cells. Interleukin 2 (IL-2), produced by activated T cells, induces the proliferation and differentiation on T and B cells. In this report, the signal requirement for the activation of T cells in C57BL/6 mice was examined in in vitro responses to mutant MHC class I antigen (H-2K^). From our observations, activation of T cells responding to MHC class I antigen could be explained as follows. Lyt 2^+ T cells recognize directly the mutant MHC class I antigen and then IL-1 receptor (IL-1R) and IL-2 receptor (IL-2R) appear on the T cells. Accessory cells secrete IL-1 upon the binding of T cells. The secreted IL-1 may bind IL-1R on the responding T cells and induce production of IL-2, which binds to IL-2R. Thus, T cell proliferation and CTL (cytotoxic T lymphocyte) generation will proceed autonomously.}, pages = {350--353}, title = {3) アロ抗原反応性Tリンパ球の活性化におけるIL-1とIL-2の役割(シンポジウム Growth Factorの基礎と臨床, 第434回新潟医学会)}, volume = {103}, year = {1989} }